A flexible virus-like particle delivery platform for next-generation vaccines

用于下一代疫苗的灵活的类病毒颗粒递送平台

• 批准号: DE140101553
• 负责人: Dr Frank Sainsbury
• 金额: $ 27.88万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-02-25
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE140101553
• 关键词: flexible; virus; like; particle; delivery

Murine polyomavirus (MPyV) capsid proteins self-assemble into spherical protein shells approximately 45 nm in diameter. Such virus-like particles (VLPs) are of considerable interest as bionanotechnological tools. The unique flexibility provided by MPyV VLPs will be exploited by exploring the ability of the interior cavity to retain bioactive cargos while engineering novel functionality on the exterior surface by 'mix-and-match' assembly of VLPs from modified components. As a proof of concept for next-generation vaccines that stimulate much needed, broadly protective responses against infectious diseases, model antigens will be delivered to specific immune cells using this nano-container.

鼠多瘤病毒（MPyV）衣壳蛋白自组装成直径约45 nm的球形蛋白壳。这种病毒样颗粒（VLP）作为生物纳米技术工具具有相当大的兴趣。MPyV VLP提供的独特灵活性将通过探索内腔保留生物活性货物的能力来开发，同时通过由改性组分“混合匹配”组装VLP在外表面上设计新的功能。作为下一代疫苗的概念证明，这些疫苗刺激了急需的、广泛的保护性反应，以对抗传染病，模型抗原将使用这种纳米容器被递送到特定的免疫细胞。