Functional Role of NREM sleep oscillations in aging

NREM 睡眠振荡在衰老中的功能作用

• 批准号: RGPIN-2016-05149
• 负责人: Carrier, Julie
• 金额: $ 3.72万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=615527
• 关键词: Functional; Role; NREM; sleep; oscillations

Aging is associated with important modifications in sleep including shorter sleep duration, shallower sleep and reductions in specific brain waves (or oscillations of the brain activity) such as slow-waves and spindles. Specific components of declarative memory consolidation (i.e. ability to recall explicitly facts and events) also decline significantly with normal aging. Importantly, slow-waves and spindles play an important role in reinforcing cerebral memory traces during sleep. The long-term objective of this research program is to understand the functional role of sleep oscillations in aging. Specifically, we will use a multi-modal approach to test the hypothesis that age-related changes in sleep oscillations are associated with changes in the ability of the brain to strengthen declarative memory. Our first specific objective is to localize on the cortex synchronous activity and evaluate how these cortical areas communicate together during sleep oscillations after learning a declarative memory task in young and older participants. We predict that synchrony during sleep oscillations will emerge from a broader and more connected set of cortical regions after learning, as compared to the control task. We also expect that these effects will be less pronounced in older participants and that performance on the retention of a declarative memory task in the morning will be associated to enhanced cortical communication during sleep oscillations. Our second specific objective is to evaluate the effects of inducing weak electric currents on specific areas on the scalp to induce sleep oscillations and enhance retention on a declarative memory task in young and older participants. We predict that compared to a control condition, sleep oscillations will be enhanced in the young and, in particular, in the older participants, which will improve the retention on a declarative memory task. The research program will provide crucial knowledge as to how age-related changes in sleep oscillations are associated with changes in brain plasticity. The development of a methodology to induce sleep oscillations provides an innovative causal approach to assess the role of sleep oscillations. In the spirit of the NSERC mandate, this research program will also stimulate the development of new methodology (electromagnetic neuroimaging) and advanced technological devices (wave-based neurostimulation). The overall objective is the enhancement of brain plasticity during sleep in specific populations which show sleep oscillations abnormalities (e.g. mild cognitive impairment and Parkinson disease).

衰老与睡眠的重要变化有关，包括睡眠时间缩短，睡眠浅和特定脑电波（或大脑活动的振荡）减少，如慢波和纺锤波。陈述性记忆巩固的特定成分（即明确回忆事实和事件的能力）也会随着正常衰老而显着下降。重要的是，慢波和纺锤波在加强睡眠期间的大脑记忆痕迹方面发挥着重要作用。这项研究计划的长期目标是了解睡眠振荡在衰老中的功能作用。具体来说，我们将使用多模态方法来检验这一假设，即睡眠振荡中与年龄相关的变化与大脑加强陈述性记忆能力的变化有关。我们的第一个具体目标是本地化的皮层同步活动，并评估这些皮层区域如何在睡眠振荡学习后，在年轻和老年参与者的陈述性记忆任务一起沟通。我们预测，与控制任务相比，睡眠振荡期间的同步性将在学习后从一组更广泛和更连接的皮层区域中出现。我们还预计，这些影响在老年参与者中将不那么明显，并且在早晨保留陈述性记忆任务的表现将与睡眠振荡期间增强的皮层通信相关。我们的第二个具体目标是评估在头皮上的特定区域上诱导弱电流以诱导睡眠振荡并增强年轻和老年参与者在陈述性记忆任务上的保留的影响。我们预测，与对照条件相比，年轻人的睡眠振荡将得到增强，特别是老年人，这将改善陈述性记忆任务的保留。该研究计划将提供有关睡眠振荡中年龄相关变化如何与大脑可塑性变化相关的关键知识。诱导睡眠振荡的方法的发展提供了一种创新的因果关系的方法来评估睡眠振荡的作用。在NSERC的授权精神下，该研究计划还将刺激新方法（电磁神经成像）和先进技术设备（基于波的神经刺激）的开发。总体目标是在显示睡眠振荡异常（例如轻度认知障碍和帕金森病）的特定人群中增强睡眠期间的脑可塑性。