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The link between NREM sleep oscillations and brain plasticity

NREM 睡眠振荡与大脑可塑性之间的联系

基本信息

批准号：
222867-2011
负责人：
Carrier, Julie
金额：
$ 3.79万
依托单位：
Université de Montréal
依托单位国家：
加拿大
项目类别：
Discovery Grants Program - Individual
财政年份：
2011
资助国家：
加拿大
起止时间：
2011-01-01 至 2012-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=478259
关键词：
link between NREM sleep oscillations

项目摘要

Sleep plays a crucial role in learning and memory. Increasing evidence supports the idea that brain areas that have been used more than others need more sleep. Specific types of brain waves (measured with an electroencephalogram) during non-rapid-eye-movement (NREM) sleep, such as slow waves (0.3-4 Hz) and spindles (12-15 Hz), are particularly involved in brain plasticity, i.e. the ability to reorganize neural pathways based on experience. Interestingly, our research showed that aging strongly modulates slow waves and spindle during sleep. Yet the mechanisms underlying age-related changes in slow waves and spindles and their functional consequences are still unknown. Our main hypothesis is that age-related changes in slow waves and spindles are associated with changes in the brain's ability to reorganize neural pathways. To test this, we will evaluate how sleep impacts brain plasticity and how changes in brain plasticity modify sleep in young and older subjects. Specifically, we will assess whether a 12-hour interval with or without sleep better maintains cerebral plasticity induced by transcranial magnetic stimulation (an innovative technique to manipulate brain activity) or performance on a memory task and consequent cerebral activation, as measured with brain imaging. We will also evaluate in young and older subjects how a change in brain activity induced by transcranial magnetic stimulation or a memory task impacts slow waves and spindles during subsequent sleep. We hope to provide essential cues as to how age-related changes in NREM sleep oscillations and in brain plasticity are interrelated.

睡眠在学习和记忆中起着至关重要的作用。越来越多的证据支持这一观点，即使用较多的大脑区域比其他区域需要更多的睡眠。非快速眼动 (NREM) 睡眠期间的特定类型脑电波（通过脑电图测量），例如慢波 (0.3-4 Hz) 和纺锤波 (12-15 Hz)，特别与大脑可塑性有关，即根据经验重组神经通路的能力。有趣的是，我们的研究表明，衰老会强烈调节睡眠期间的慢波和纺锤波。然而，慢波和纺锤体与年龄相关的变化背后的机制及其功能后果仍然未知。我们的主要假设是，慢波和纺锤体与年龄相关的变化与大脑重组神经通路的能力的变化有关。为了测试这一点，我们将评估睡眠如何影响大脑可塑性以及大脑可塑性的变化如何改变年轻和老年受试者的睡眠。具体来说，我们将评估 12 小时的睡眠或不睡眠间隔是否能更好地维持经颅磁刺激（一种操纵大脑活动的创新技术）诱导的大脑可塑性或记忆任务的表现以及随后的大脑激活（通过大脑成像测量）。我们还将在年轻和年长的受试者中评估经颅磁刺激或记忆任务引起的大脑活动变化如何影响随后睡眠期间的慢波和纺锤波。我们希望提供重要线索，说明 NREM 睡眠振荡与年龄相关的变化和大脑可塑性如何相互关联。