Functions of the bile acids receptor FXR in intestinal epithelium

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Bile acids are detergent synthesized in the liver and released into the small intestine to facilitate the absorption of dietary lipids. Bile acids are absorbed in the end of the small intestine to be return to the liver where they are recycled. Ten years ago, the discovery of a receptor for bile acids that regulates its production by the liver and absorption by the intestine markedly expand our understanding of this process. More recently, it has been found that bile acids receptor plays broader roles and often counteracts the deleterious effect of excessive bile acids. Dr Carrier concentrates her research effort on nuclear receptors in which the bile acids receptor belongs, and she applies this field to intestinal physiology. Our preliminary results demonstrated that the activation of bile acids receptor reduced cell growth but promote specialization into functional epithelial cells lining the inside of the small intestine.