Development and validation of novel bioactive porous biodegradable metals for high performance biomaterials

用于高性能生物材料的新型生物活性多孔可生物降解金属的开发和验证

• 批准号: RGPIN-2016-05915
• 负责人: Hermawan, Hendra
• 金额: $ 2.04万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=615986
• 关键词: Development; validation; novel; bioactive; porous

According to the Web of Science core collection, reported works on biodegradable metals (BM) for biomedical applications have been growing from <50 publications in 2005 to >2,000 publications over the past 10 years. These metals have been attracting researchers in academia and medical industries alike as they can potentially revolutionize the medical products. The development of BM is fostered by the advancing knowledge in the science and engineering of materials, the science of corrosion and the technology of metal processing. One of the latest specific development is the introduction of porous BM that offer great potential as bone scaffold materials with optimum strength and corrosion behavior. The future of BM research goes toward developing new BM with bio-functionalities and establishing specific experimental procedures. Having worked in the material science and corrosion aspects of BM research for the past 5 years, I am proposing this NSERC discovery program with long-term objective to develop world-recognized expertise in novel BM and their corrosion assessment. Within 5 years, the program has 2 short-term objectives (STOs) to be achieved in 2 structured lines: STO-1: Developing bioactive iron-based porous BM in view of bone scaffold applications; STO-2: Assessing their corrosion behavior under a simulated condition of bone environment. The research in STO-1 has been initiated with works on the development of new composites of porous iron-poly(lactic-co-glycolic acid) as reported in Nature’s Scientific Reports. We will further develop the porous iron as a backbone for incorporating different polymers and bioactive compounds and to investigate the fundamentals of structure-process-property relationship. Within STO-2, we focus on assessing their corrosion behavior using a test-bench that simulates bone environment integrated with an online corrosion monitoring system. We have previously worked in developing a microdialysis-based monitoring system and a test-bench for simulating arterial condition. Within 5 years, we will address the current challenge and need for bioactive biomaterials and specific corrosion assessment methods. We will bring valid evidence of porous BM potentiality as new bioactive biomaterials with optimum mechanical and corrosion properties. We also envisage to create new technological platforms applicable to other fields including bioactive porous composites or membranes for catalysis and online monitoring system for internal corrosion of pipeline and other equipment in oil and gas industry. In this discovery program, we both advance knowledge and train highly qualified personnel (HQP) to acquire expertise in the key areas for Canada. By utilizing my seed fund as new professor, 3 HQPs were recruited and are initiating work planned in this program. The support from NSERC discovery grant will be a big aid for the continuation of their work and training.

根据Web of Science核心数据库，在过去的10年里，关于生物可降解金属（BM）在生物医学应用方面的报道已经从2,000<50 publications in 2005 to >篇出版物增加到了2,000篇。这些金属一直吸引着学术界和医疗行业的研究人员，因为它们可能会彻底改变医疗产品。BM的发展得益于材料科学和工程、腐蚀科学和金属加工技术的先进知识。最新的具体进展之一是引入多孔BM，其作为具有最佳强度和腐蚀行为的骨支架材料具有巨大潜力。BM研究的未来是开发具有生物功能的新BM和建立特定的实验程序。 在过去的5年里，我一直从事BM研究的材料科学和腐蚀方面的工作，我提出了这个NSERC发现计划，其长期目标是在新型BM及其腐蚀评估方面发展世界公认的专业知识。在5年内，该计划有2个短期目标（STO），将在2个结构化的路线中实现：STO-1：开发生物活性铁基多孔BM，考虑到骨支架应用; STO-2：评估其在模拟骨环境条件下的腐蚀行为。STO-1的研究已经开始了多孔铁-聚（乳酸-乙醇酸共聚物）新复合材料的开发工作，如《自然》科学报告所述。我们将进一步开发多孔铁作为骨架，用于掺入不同的聚合物和生物活性化合物，并研究结构-工艺-性能关系的基本原理。在STO-2中，我们专注于使用模拟骨环境的测试台架与在线腐蚀监测系统集成来评估其腐蚀行为。我们以前曾在开发微透析为基础的监测系统和模拟动脉状况的测试台。 在5年内，我们将解决目前的挑战和生物活性生物材料和特定的腐蚀评估方法的需求。我们将带来有效的证据，多孔BM潜力作为新的生物活性生物材料具有最佳的机械和腐蚀性能。我们还设想创建适用于其他领域的新技术平台，包括用于催化的生物活性多孔复合材料或膜，以及用于石油和天然气工业中管道和其他设备的内腐蚀在线监测系统。在这个发现计划中，我们既推进知识，又培训高素质人员（HQP），以获得加拿大关键领域的专业知识。通过利用我的种子基金作为新的教授，3 HQP被招募，并开始在这个程序计划的工作。NSERC发现补助金的支持将是他们继续工作和培训的一大帮助。