The regulation of heterotirmeric G protein signaling by interacting proteins in plants
植物中相互作用蛋白对异三聚体 G 蛋白信号传导的调节
基本信息
- 批准号:RGPIN-2016-06671
- 负责人:
- 金额:$ 2.4万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2016
- 资助国家:加拿大
- 起止时间:2016-01-01 至 2017-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Our work is directed toward understanding the basis of plant tolerance to environmental stresses including drought, salt and low temperature stress. We are investigating the fundamental genetic and molecular responses to environmental stress in order to understand the basis of tolerance to stress and develop strategies to improve tolerance to drought and salt toxicity. Unpredictable changes in climatic conditions, including drought and extreme temperatures pose challenging and costly risks to agriculture. Plants have a wide genetic variation for stress tolerance and throughout the history of agriculture there has been genetic selection for improved yield under stress conditions. The need to improve tolerance in plants is increased by changing climatic conditions and the success in achieving improvements will be dependent on understanding the biological mechanisms underpinning stress tolerance. My laboratory has identified a large number of regulatory genes in wheat whose change in expression correlates with the level of tolerance of wheat different genotypes.
Presently we are investigating some of these candidate tolerance genes at the molecular level in the model species Arabidopsis. We are asking how caleosin genes RD20/CLO3, and CLO7 interact with molecular signaling pathways that control root growth and the density of stomata on the leaf surface. High root density and deep root penetration in the soil contributes to the plants ability to take up water from the soil, when water availability is limited. Stomata are small valves on the surface of the leaf that can open and close and control the water loss and gas exchange, most importantly CO2 uptake from the atmosphere during photosynthesis. Our work focuses on the function of the caleosin genes in their interaction with a class of proteins referred to as heterotrimeric G proteins, or G-proteins, that function as signaling molecules, that is, on/off switches that can control the degree of root growth, and stomatal development.
The regulation of the density of stomata is known to be complex and controlled by genes that act in a signal transduction circuit. We have discovered that stress-induced caleosins interact with G-proteins and that they control stomatal density in response to stress signals. It is unknown how the caleosins and G-proteins interconnect with the stomatal development signaling pathway. One of our major objectives is to discover how these two signalling pathways are interconnected at the molecular level. The development of detailed knowledge of the regulation of root development, stomatal development and the control of stomatal opening can be used as the basis of plant improvement in order to develop crops that are more tolerant to drought, salt and extreme weather conditions.
我们的工作旨在了解植物对干旱、盐和低温等环境胁迫的耐受性基础。我们正在研究对环境胁迫的基本遗传和分子反应,以了解对胁迫的耐受性的基础,并制定策略来提高对干旱和盐毒性的耐受性。气候条件的不可预测变化,包括干旱和极端气温,给农业带来了具有挑战性和代价高昂的风险。植物对胁迫耐受性具有广泛的遗传变异,并且在整个农业历史中,存在用于在胁迫条件下提高产量的遗传选择。气候条件的变化增加了提高植物耐受性的需求,而实现改善的成功将取决于对支撑胁迫耐受性的生物学机制的理解。本实验室已经鉴定了大量小麦中的调控基因,它们的表达变化与小麦不同基因型的耐性水平相关。
目前,我们正在模式植物拟南芥中对这些候选的耐药基因进行分子水平的研究。我们正在研究caleosin基因RD 20/CLO 3和CLO 7如何与控制根生长和叶表面气孔密度的分子信号通路相互作用。当水的可利用性有限时,高的根密度和深的根在土壤中的渗透有助于植物从土壤中吸收水的能力。气孔是叶子表面的小阀门,可以打开和关闭并控制水分散失和气体交换,最重要的是光合作用过程中从大气中吸收二氧化碳。我们的工作集中在caleosin基因的功能,在他们的相互作用与一类蛋白质被称为异三聚体G蛋白,或G蛋白,功能作为信号分子,即开/关开关,可以控制的程度根的生长,气孔发育。
已知气孔密度的调节是复杂的,并且由在信号传导回路中起作用的基因控制。我们已经发现,应力诱导的caleosins与G-蛋白相互作用,它们控制气孔密度响应应力信号。目前尚不清楚Caleosins和G蛋白如何与气孔发育信号通路相互联系。我们的主要目标之一是发现这两个信号通路是如何在分子水平上相互联系的。对根系发育、气孔发育和气孔开度控制的详细了解,可作为植物改良的基础,以培育出更耐干旱、盐和极端气候条件的作物。
项目成果
期刊论文数量(0)
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Gulick, Patrick其他文献
Gulick, Patrick的其他文献
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{{ truncateString('Gulick, Patrick', 18)}}的其他基金
The regulation of heterotirmeric G protein signaling by interacting proteins in plants
植物中相互作用蛋白对异三聚体 G 蛋白信号传导的调节
- 批准号:
RGPIN-2016-06671 - 财政年份:2021
- 资助金额:
$ 2.4万 - 项目类别:
Discovery Grants Program - Individual
The regulation of heterotirmeric G protein signaling by interacting proteins in plants
植物中相互作用蛋白对异三聚体 G 蛋白信号传导的调节
- 批准号:
RGPIN-2016-06671 - 财政年份:2020
- 资助金额:
$ 2.4万 - 项目类别:
Discovery Grants Program - Individual
The regulation of heterotirmeric G protein signaling by interacting proteins in plants
植物中相互作用蛋白对异三聚体 G 蛋白信号传导的调节
- 批准号:
RGPIN-2016-06671 - 财政年份:2019
- 资助金额:
$ 2.4万 - 项目类别:
Discovery Grants Program - Individual
The regulation of heterotirmeric G protein signaling by interacting proteins in plants
植物中相互作用蛋白对异三聚体 G 蛋白信号传导的调节
- 批准号:
RGPIN-2016-06671 - 财政年份:2018
- 资助金额:
$ 2.4万 - 项目类别:
Discovery Grants Program - Individual
The regulation of heterotirmeric G protein signaling by interacting proteins in plants
植物中相互作用蛋白对异三聚体 G 蛋白信号传导的调节
- 批准号:
RGPIN-2016-06671 - 财政年份:2017
- 资助金额:
$ 2.4万 - 项目类别:
Discovery Grants Program - Individual
G protein signaling in the plant response to environmental stress
植物响应环境胁迫中的 G 蛋白信号传导
- 批准号:
46326-2011 - 财政年份:2015
- 资助金额:
$ 2.4万 - 项目类别:
Discovery Grants Program - Individual
G protein signaling in the plant response to environmental stress
植物响应环境胁迫中的 G 蛋白信号传导
- 批准号:
46326-2011 - 财政年份:2014
- 资助金额:
$ 2.4万 - 项目类别:
Discovery Grants Program - Individual
G protein signaling in the plant response to environmental stress
植物响应环境胁迫中的 G 蛋白信号传导
- 批准号:
46326-2011 - 财政年份:2013
- 资助金额:
$ 2.4万 - 项目类别:
Discovery Grants Program - Individual
G protein signaling in the plant response to environmental stress
植物响应环境胁迫中的 G 蛋白信号传导
- 批准号:
46326-2011 - 财政年份:2012
- 资助金额:
$ 2.4万 - 项目类别:
Discovery Grants Program - Individual
G protein signaling in the plant response to environmental stress
植物响应环境胁迫中的 G 蛋白信号传导
- 批准号:
46326-2011 - 财政年份:2011
- 资助金额:
$ 2.4万 - 项目类别:
Discovery Grants Program - Individual
相似海外基金
The regulation of heterotirmeric G protein signaling by interacting proteins in plants
植物中相互作用蛋白对异三聚体 G 蛋白信号传导的调节
- 批准号:
RGPIN-2016-06671 - 财政年份:2021
- 资助金额:
$ 2.4万 - 项目类别:
Discovery Grants Program - Individual
The regulation of heterotirmeric G protein signaling by interacting proteins in plants
植物中相互作用蛋白对异三聚体 G 蛋白信号传导的调节
- 批准号:
RGPIN-2016-06671 - 财政年份:2020
- 资助金额:
$ 2.4万 - 项目类别:
Discovery Grants Program - Individual
The regulation of heterotirmeric G protein signaling by interacting proteins in plants
植物中相互作用蛋白对异三聚体 G 蛋白信号传导的调节
- 批准号:
RGPIN-2016-06671 - 财政年份:2019
- 资助金额:
$ 2.4万 - 项目类别:
Discovery Grants Program - Individual
The regulation of heterotirmeric G protein signaling by interacting proteins in plants
植物中相互作用蛋白对异三聚体 G 蛋白信号传导的调节
- 批准号:
RGPIN-2016-06671 - 财政年份:2018
- 资助金额:
$ 2.4万 - 项目类别:
Discovery Grants Program - Individual
The regulation of heterotirmeric G protein signaling by interacting proteins in plants
植物中相互作用蛋白对异三聚体 G 蛋白信号传导的调节
- 批准号:
RGPIN-2016-06671 - 财政年份:2017
- 资助金额:
$ 2.4万 - 项目类别:
Discovery Grants Program - Individual