The regulation of heterotirmeric G protein signaling by interacting proteins in plants

植物中相互作用蛋白对异三聚体 G 蛋白信号传导的调节

基本信息

  • 批准号:
    RGPIN-2016-06671
  • 负责人:
  • 金额:
    $ 2.4万
  • 依托单位:
  • 依托单位国家:
    加拿大
  • 项目类别:
    Discovery Grants Program - Individual
  • 财政年份:
    2019
  • 资助国家:
    加拿大
  • 起止时间:
    2019-01-01 至 2020-12-31
  • 项目状态:
    已结题

项目摘要

Our work is directed toward understanding the basis of plant tolerance to environmental stresses including drought, salt and low temperature stress. We are investigating the fundamental genetic and molecular responses to environmental stress in order to understand the basis of tolerance to stress and develop strategies to improve tolerance to drought and salt toxicity. Unpredictable changes in climatic conditions, including drought and extreme temperatures pose challenging and costly risks to agriculture. Plants have a wide genetic variation for stress tolerance and throughout the history of agriculture there has been genetic selection for improved yield under stress conditions. The need to improve tolerance in plants is increased by changing climatic conditions and the success in achieving improvements will be dependent on understanding the biological mechanisms underpinning stress tolerance. My laboratory has identified a large number of regulatory genes in wheat whose change in expression correlates with the level of tolerance of wheat different genotypes.***Presently we are investigating some of these candidate tolerance genes at the molecular level in the model species Arabidopsis. We are asking how caleosin genes RD20/CLO3, and CLO7 interact with molecular signaling pathways that control root growth and the density of stomata on the leaf surface. High root density and deep root penetration in the soil contributes to the plants ability to take up water from the soil, when water availability is limited. Stomata are small valves on the surface of the leaf that can open and close and control the water loss and gas exchange, most importantly CO2 uptake from the atmosphere during photosynthesis. Our work focuses on the function of the caleosin genes in their interaction with a class of proteins referred to as heterotrimeric G proteins, or G-proteins, that function as signaling molecules, that is, on/off switches that can control the degree of root growth, and stomatal development. ***The regulation of the density of stomata is known to be complex and controlled by genes that act in a signal transduction circuit. We have discovered that stress-induced caleosins interact with G-proteins and that they control stomatal density in response to stress signals. It is unknown how the caleosins and G-proteins interconnect with the stomatal development signaling pathway. One of our major objectives is to discover how these two signalling pathways are interconnected at the molecular level. The development of detailed knowledge of the regulation of root development, stomatal development and the control of stomatal opening can be used as the basis of plant improvement in order to develop crops that are more tolerant to drought, salt and extreme weather conditions. **
我们的工作旨在了解植物对环境胁迫的耐受性基础,包括干旱、盐和低温胁迫。我们正在研究对环境胁迫的基本遗传和分子反应,以了解对胁迫的耐受性基础,并制定策略来提高对干旱和盐毒性的耐受性。气候条件的不可预测变化,包括干旱和极端温度,给农业带来了挑战和代价高昂的风险。植物具有广泛的抗逆性遗传变异,在整个农业历史中,在逆境条件下提高产量的遗传选择一直存在。气候条件的变化增加了提高植物耐受性的需要,而实现改善的成功将取决于理解支撑抗逆性的生物机制。我的实验室已经在小麦中发现了大量的调控基因,这些基因的表达变化与小麦不同基因型的耐受性水平有关。***目前,我们正在模式物种拟南芥的分子水平上研究这些候选耐受性基因。我们正在研究钙红蛋白基因RD20/CLO3和CLO7如何与控制根系生长和叶表面气孔密度的分子信号通路相互作用。土壤中较高的根系密度和较深的根系渗透有助于植物在水分有限的情况下从土壤中吸收水分。气孔是叶子表面的小阀门,可以打开和关闭,控制水分流失和气体交换,最重要的是光合作用期间从大气中吸收二氧化碳。我们的工作重点是caleosin基因在与一类称为异源三聚体G蛋白或G蛋白的蛋白质相互作用中的功能,G蛋白作为信号分子,即可以控制根生长程度和气孔发育的开关。***气孔密度的调控是非常复杂的,由参与信号转导回路的基因控制。我们已经发现,应激诱导的钙调蛋白与g蛋白相互作用,它们在响应应激信号时控制气孔密度。钙调蛋白和g蛋白是如何与气孔发育信号通路相互联系的尚不清楚。我们的主要目标之一是发现这两种信号通路在分子水平上是如何相互联系的。深入了解根系发育、气孔发育和气孔开放的调控规律,可以作为植物改良的基础,从而培育出更耐旱、耐盐和极端气候条件的作物。**

项目成果

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Gulick, Patrick其他文献

Gulick, Patrick的其他文献

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{{ truncateString('Gulick, Patrick', 18)}}的其他基金

The regulation of heterotirmeric G protein signaling by interacting proteins in plants
植物中相互作用蛋白对异三聚体 G 蛋白信号传导的调节
  • 批准号:
    RGPIN-2016-06671
  • 财政年份:
    2021
  • 资助金额:
    $ 2.4万
  • 项目类别:
    Discovery Grants Program - Individual
The regulation of heterotirmeric G protein signaling by interacting proteins in plants
植物中相互作用蛋白对异三聚体 G 蛋白信号传导的调节
  • 批准号:
    RGPIN-2016-06671
  • 财政年份:
    2020
  • 资助金额:
    $ 2.4万
  • 项目类别:
    Discovery Grants Program - Individual
The regulation of heterotirmeric G protein signaling by interacting proteins in plants
植物中相互作用蛋白对异三聚体 G 蛋白信号传导的调节
  • 批准号:
    RGPIN-2016-06671
  • 财政年份:
    2018
  • 资助金额:
    $ 2.4万
  • 项目类别:
    Discovery Grants Program - Individual
The regulation of heterotirmeric G protein signaling by interacting proteins in plants
植物中相互作用蛋白对异三聚体 G 蛋白信号传导的调节
  • 批准号:
    RGPIN-2016-06671
  • 财政年份:
    2017
  • 资助金额:
    $ 2.4万
  • 项目类别:
    Discovery Grants Program - Individual
The regulation of heterotirmeric G protein signaling by interacting proteins in plants
植物中相互作用蛋白对异三聚体 G 蛋白信号传导的调节
  • 批准号:
    RGPIN-2016-06671
  • 财政年份:
    2016
  • 资助金额:
    $ 2.4万
  • 项目类别:
    Discovery Grants Program - Individual
G protein signaling in the plant response to environmental stress
植物响应环境胁迫中的 G 蛋白信号传导
  • 批准号:
    46326-2011
  • 财政年份:
    2015
  • 资助金额:
    $ 2.4万
  • 项目类别:
    Discovery Grants Program - Individual
G protein signaling in the plant response to environmental stress
植物响应环境胁迫中的 G 蛋白信号传导
  • 批准号:
    46326-2011
  • 财政年份:
    2014
  • 资助金额:
    $ 2.4万
  • 项目类别:
    Discovery Grants Program - Individual
G protein signaling in the plant response to environmental stress
植物响应环境胁迫中的 G 蛋白信号传导
  • 批准号:
    46326-2011
  • 财政年份:
    2013
  • 资助金额:
    $ 2.4万
  • 项目类别:
    Discovery Grants Program - Individual
G protein signaling in the plant response to environmental stress
植物响应环境胁迫中的 G 蛋白信号传导
  • 批准号:
    46326-2011
  • 财政年份:
    2012
  • 资助金额:
    $ 2.4万
  • 项目类别:
    Discovery Grants Program - Individual
G protein signaling in the plant response to environmental stress
植物响应环境胁迫中的 G 蛋白信号传导
  • 批准号:
    46326-2011
  • 财政年份:
    2011
  • 资助金额:
    $ 2.4万
  • 项目类别:
    Discovery Grants Program - Individual

相似海外基金

The regulation of heterotirmeric G protein signaling by interacting proteins in plants
植物中相互作用蛋白对异三聚体 G 蛋白信号传导的调节
  • 批准号:
    RGPIN-2016-06671
  • 财政年份:
    2021
  • 资助金额:
    $ 2.4万
  • 项目类别:
    Discovery Grants Program - Individual
The regulation of heterotirmeric G protein signaling by interacting proteins in plants
植物中相互作用蛋白对异三聚体 G 蛋白信号传导的调节
  • 批准号:
    RGPIN-2016-06671
  • 财政年份:
    2020
  • 资助金额:
    $ 2.4万
  • 项目类别:
    Discovery Grants Program - Individual
The regulation of heterotirmeric G protein signaling by interacting proteins in plants
植物中相互作用蛋白对异三聚体 G 蛋白信号传导的调节
  • 批准号:
    RGPIN-2016-06671
  • 财政年份:
    2018
  • 资助金额:
    $ 2.4万
  • 项目类别:
    Discovery Grants Program - Individual
The regulation of heterotirmeric G protein signaling by interacting proteins in plants
植物中相互作用蛋白对异三聚体 G 蛋白信号传导的调节
  • 批准号:
    RGPIN-2016-06671
  • 财政年份:
    2017
  • 资助金额:
    $ 2.4万
  • 项目类别:
    Discovery Grants Program - Individual
The regulation of heterotirmeric G protein signaling by interacting proteins in plants
植物中相互作用蛋白对异三聚体 G 蛋白信号传导的调节
  • 批准号:
    RGPIN-2016-06671
  • 财政年份:
    2016
  • 资助金额:
    $ 2.4万
  • 项目类别:
    Discovery Grants Program - Individual
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