Critical need for a new chiller for the Aquatic Toxicology Research Facility, Toxicology Centre, University of Saskatchewan

萨斯喀彻温大学毒理学中心水生毒理学研究设施迫切需要一台新型冷水机

基本信息

  • 批准号:
    RTI-2017-00773
  • 负责人:
  • 金额:
    $ 10.87万
  • 依托单位:
  • 依托单位国家:
    加拿大
  • 项目类别:
    Research Tools and Instruments
  • 财政年份:
    2016
  • 资助国家:
    加拿大
  • 起止时间:
    2016-01-01 至 2017-12-31
  • 项目状态:
    已结题

项目摘要

The Aquatic Toxicology Research Facility (ATRF) is the only multi-user aquatic facility of its type in Canada, and is housed within the Toxicology Centre, University of Saskatchewan (U of S). The ATRF allows researchers to study the impacts of contaminants and other stressors on a broad range of freshwater aquatic organisms ranging from microorganisms to fish and amphibians, under controlled environmental conditions. The ATRF is utilized by Canadian and International investigators independently or through research partnerships with Toxicology Centre scientists, and provides an ideal training ground for HQP. The design of the facility allows for highly specialized experimental design and delivery of water of customized quality/temperature to simulate natural environments. To continue to meet the current and future needs of researchers, the ATRF water chiller must be replaced and upgraded for continued operation of the facility. The aging ATRF chiller has reached its operational lifespan and a new chiller is essential to continue to support research. Also, the needs of researchers using the facility are evolving and the ability of the ATRF to support novel and state-of-the-art large multi-facet research projects is vital to maintain its unique status in Canada and beyond. Replacing the failing chiller with a more advanced chilling system to provide optimal delivery of stable temperature cold water will be critical to meet current needs, and enable future success of the highly innovative, high impact research programs of researchers. We currently have over 200 tanks and other experimental units that are used by more than 10 researchers, 30 HQP and 13 research projects (including a $9.6M Genome Canada and a $70M CFREF grant) relying on stable cold temperature water supply. The proposed 40 ton chiller will be able to accommodate the 5°C - 22°C seasonal fluctuations in city water temperature and produce 151 lpm of 10°C water year round. The new chiller has two separate circuits that provide built in redundancy and flexibility for the ATRF, which is critical to allow optimal and uninterrupted water delivery that will prevent disruption of ongoing research projects and provide optimal aquatic animal care. In addition, this chiller will increase our current water chilling capacity and delivery, ensuring that researchers are able to meet novel research challenges and continue running large-scale experiments with cold-water organisms, and thus provide a strong foundation for HQP training and advancement of their research programs. The ATRF is an essential component of a large number of NSERC-funded research programs at the U of S that focus on aquatic toxicology research. In addition, researchers from other universities, government and industry have recognized the uniqueness and capabilities of the facility that are utilizing/have utilized the ATRF to address their research needs.
水生毒理学研究设施(ATRF)是加拿大唯一的多用户水生设施,位于萨斯喀彻温大学(U of S)毒理学中心。ATRF使研究人员能够在受控的环境条件下研究污染物和其他压力源对从微生物到鱼类和两栖动物等各种淡水水生生物的影响。ATRF由加拿大和国际研究人员独立使用,或通过与毒理学中心科学家的研究伙伴关系使用,并为HQP提供了理想的培训基地。该设施的设计允许高度专业化的实验设计和定制质量/温度的水的交付,以模拟自然环境。 为了继续满足研究人员当前和未来的需求,ATRF冷水机组必须进行更换和升级,以便继续运行该设施。老化的ATRF制冷机已达到其使用寿命,新的制冷机对于继续支持研究至关重要。此外,使用该设施的研究人员的需求正在不断变化,ATRF支持新颖和最先进的大型多方面研究项目的能力对于保持其在加拿大及其他地区的独特地位至关重要。用更先进的冷却系统取代故障的冷水机组,以提供最佳的温度稳定的冷水输送,对于满足当前的需求至关重要,并使研究人员的高度创新,高影响力的研究计划能够在未来取得成功。我们目前拥有200多个水箱和其他实验单元,供10多名研究人员、30名HQP和13个研究项目(包括960万美元的加拿大基因组研究和7000万美元的CFREF资助)使用,这些项目依赖于稳定的冷水供应。拟议的40吨冷水机组将能够适应城市水温5°C - 22°C的季节性波动,并全年生产151 lpm的10°C水。新的制冷机有两个独立的回路,为ATRF提供内置冗余和灵活性,这对于实现最佳和不间断的供水至关重要,这将防止正在进行的研究项目中断,并提供最佳的水生动物护理。此外,该冷水机组将提高我们目前的水冷却能力和输送能力,确保研究人员能够应对新的研究挑战,并继续进行冷水生物的大规模实验,从而为HQP培训和推进其研究计划提供坚实的基础。 ATRF是美国NSERC资助的大量研究项目的重要组成部分,这些项目专注于水生毒理学研究。此外,来自其他大学、政府和工业界的研究人员已经认识到该设施的独特性和能力,这些设施正在利用/已经利用ATRF来满足他们的研究需求。

项目成果

期刊论文数量(0)
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Hecker, Markus其他文献

Cyclic stretch controls the expression of CD40 in endothelial cells by changing their transforming growth factor-β1 response
  • DOI:
    10.1161/circulationaha.107.730309
  • 发表时间:
    2007-11-13
  • 期刊:
  • 影响因子:
    37.8
  • 作者:
    Korff, Thomas;Aufgebauer, Karin;Hecker, Markus
  • 通讯作者:
    Hecker, Markus
The OECD validation program of the H295R steroidogenesis assay: Phase 3. Final inter-laboratory validation study
Polychlorinated naphthalenes and other dioxin-like compounds in Elbe River sediments
  • DOI:
    10.1897/07-400.1
  • 发表时间:
    2008-03-01
  • 期刊:
  • 影响因子:
    4.1
  • 作者:
    Brack, Werner;Blaha, Ludek;Hecker, Markus
  • 通讯作者:
    Hecker, Markus
Distress-Mediated Remodeling of Cardiac Connexin-43 in a Novel Cell Model for Arrhythmogenic Heart Diseases.
  • DOI:
    10.3390/ijms231710174
  • 发表时间:
    2022-09-05
  • 期刊:
  • 影响因子:
    5.6
  • 作者:
    Wahl, Carl-Mattheis;Schmidt, Constanze;Hecker, Markus;Ullrich, Nina D.
  • 通讯作者:
    Ullrich, Nina D.
Transcription factor decoy technology: A therapeutic update
  • DOI:
    10.1016/j.bcp.2017.06.122
  • 发表时间:
    2017-11-15
  • 期刊:
  • 影响因子:
    5.8
  • 作者:
    Hecker, Markus;Wagner, Andreas H.
  • 通讯作者:
    Wagner, Andreas H.

Hecker, Markus的其他文献

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{{ truncateString('Hecker, Markus', 18)}}的其他基金

Functional Omics of Native Fish Species for Improved Environmental Risk Assessment
本地鱼类的功能组学用于改进环境风险评估
  • 批准号:
    RGPIN-2017-05586
  • 财政年份:
    2021
  • 资助金额:
    $ 10.87万
  • 项目类别:
    Discovery Grants Program - Individual
Functional Omics of Native Fish Species for Improved Environmental Risk Assessment
本地鱼类的功能组学用于改进环境风险评估
  • 批准号:
    RGPIN-2017-05586
  • 财政年份:
    2020
  • 资助金额:
    $ 10.87万
  • 项目类别:
    Discovery Grants Program - Individual
Predictive Aquatic Ecotoxicology
预测水生生态毒理学
  • 批准号:
    1000231096-2015
  • 财政年份:
    2020
  • 资助金额:
    $ 10.87万
  • 项目类别:
    Canada Research Chairs
Functional Omics of Native Fish Species for Improved Environmental Risk Assessment
本地鱼类的功能组学用于改进环境风险评估
  • 批准号:
    RGPIN-2017-05586
  • 财政年份:
    2019
  • 资助金额:
    $ 10.87万
  • 项目类别:
    Discovery Grants Program - Individual
Predictive Aquatic Ecotoxicology
预测水生生态毒理学
  • 批准号:
    1000231096-2015
  • 财政年份:
    2019
  • 资助金额:
    $ 10.87万
  • 项目类别:
    Canada Research Chairs
Functional Omics of Native Fish Species for Improved Environmental Risk Assessment
本地鱼类的功能组学用于改进环境风险评估
  • 批准号:
    RGPIN-2017-05586
  • 财政年份:
    2018
  • 资助金额:
    $ 10.87万
  • 项目类别:
    Discovery Grants Program - Individual
Predictive Aquatic Ecotoxicology
预测水生生态毒理学
  • 批准号:
    1000231096-2015
  • 财政年份:
    2018
  • 资助金额:
    $ 10.87万
  • 项目类别:
    Canada Research Chairs
Advancing environmental risk assessment of selenium (ERASe)
推进硒的环境风险评估(ERASe)
  • 批准号:
    479047-2015
  • 财政年份:
    2017
  • 资助金额:
    $ 10.87万
  • 项目类别:
    Strategic Projects - Group
Functional Omics of Native Fish Species for Improved Environmental Risk Assessment
本地鱼类的功能组学用于改进环境风险评估
  • 批准号:
    RGPIN-2017-05586
  • 财政年份:
    2017
  • 资助金额:
    $ 10.87万
  • 项目类别:
    Discovery Grants Program - Individual
Predictive Aquatic Ecotoxicology
预测水生生态毒理学
  • 批准号:
    1000231096-2015
  • 财政年份:
    2017
  • 资助金额:
    $ 10.87万
  • 项目类别:
    Canada Research Chairs

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