An assessment of market opportunities for pro-healing polymer (PHP) technology

作为NSERCI2I市场评估提案的主题的发现/发明是一种新型合成聚合物，称为亲愈聚合物(Php)(美国大学多伦多公开号10002755，美国临时申请号62/037,359，PCT编号。PCT/CA2015/000461)。PHP有能力通过影响植入后立即被吸附的蛋白质来减少植入装置相关的炎症。与植入设备相关的主要并发症是慢性炎症反应导致的纤维性包膜的形成，在许多情况下，这可能会阻碍设备的性能。这种慢性炎症反应是由白细胞，特别是单核细胞和衍生的巨噬细胞介导的。在生物材料的外科植入后，无论它是生物医学设备的一部分还是组织工程产品的一部分，发生的第一个生物事件是从富含蛋白质的体液(例如血液、间质液)中吸附蛋白质。因此，附着在植入物上的单核细胞和巨噬细胞与生物材料相关的吸附蛋白质层相互作用，而不是直接与设备本身相互作用。PHP是由三种单体制成的，这三种单体可以选择为：(1)根据建议应用的要求提供理想的机械性能，(2)显示可生物降解/生物可再吸收或实质上不可降解的性能，以及(3)通过热固化和光固化方法制造。PHP的一个共同特征是能够调节促炎血清蛋白免疫球蛋白G(Ig G)，以限制促炎区域的暴露，从而减少可能损害种植体的粘附性单核细胞和巨噬细胞的激活。拟议市场评估的主要目的是通过评估市场规模、竞争格局、进入壁垒和市场趋势来评估拟议产品的市场潜力。还将进行分析，以评估影响技术商业化的潜在因素，包括最终用户采用产品、产品定位、潜力

The discovery/invention that is the subject of this NSERC I2I Market assessment proposal is a novel syntheticpolymer referred to as pro-healing polymer (PHP) (Univ.Toronto Disclosure No. 10002755, US provisionalapplication No.62/037,359, PCT No. PCT/CA2015/000461). PHP has the ability to reduce implant device-associatedinflammation by influencing initial adsorbed protein immediately following implantation. A majorcomplication associated with implanted devices is the formation of a fibrotic capsule as a result of a chronicinflammatory response that in many instances can impede the device's performance. This chronic inflammatoryresponse is mediated by white blood cells, particularly monocytes and derived macrophages. Following thesurgical implantation of a biomaterial, whether it is part of a biomedical device or tissue engineered product,the first biological event that occurs is the adsorption of proteins from protein-rich bodily fluids (e.g. blood,interstitial fluid). Blood monocytes and macrophages that adhere to the implants thus interact with thebiomaterial-associated adsorbed protein layer, rather than directly with the device itself. PHP is prepared usingthree monomers which can be selected to (1) provide desirable mechanical properties depending on therequirements of a proposed application, (2) exhibit biodegradable/bioresorbable or substantiallynon-degradable properties, and (3) be manufactured through both heat and light curing methods. A commonfeature of PHP is the ability to modulate the pro-inflammatory serum protein immunoglobulin G (IgG) to limitexposure of pro-inflammatory domains, thus reducing activation of adherent monocytes and macrophages thatcan damage the implant. The main aim of the proposed market assessment is to assess the market potential ofthe proposed product through assessment of market size, competitive landscape, barriers to entry, and markettrends. Analysis will also be performed to assess potential factors affecting the commercialization of thetechnology, including issues regarding product adoption by end-users, product positioning, potential