Novel adhesive polymeric membranes for binding degradable composite materials to bone in craniomaxillofacial repair

面部和颅骨的畸形(颅颌面，CMF)可由高冲击性**创伤、先天性畸形或肿瘤引起，这可能会导致功能残疾**和身体毁容。就像破碎的花瓶一样，破碎的CMF骨骼需要**对齐和稳定多块碎片才能成功重建。在重建手术中，通常使用钢板和螺丝钉，多达一半的病例会出现并发症。研究人员一直致力于开发一种用于颅骨外科重建的复合材料(骨带)**。这个概念是一种坚固的管道胶带一样的设备，可以**粘在骨头上，用于重新连接骨折块并保持它们稳定，直到它们愈合。**复合材料的特性提供了强度、多功能性和易用性的独特组合，胶带的灵活性允许包裹和粘合骨骼中复杂的骨骼轮廓**。这种复合材料也是由骨折愈合后随着时间的推移最终(而且**安全地)吸收的材料制成的，只留下修复后的骨骼。**在与工业界发展这一概念时，临床医生使用了一些商业化的牙骨水泥**，这些粘固剂不能降解，可能会产生外科医生**希望被吸收和消除的残留颗粒。因此，需要一种具有适当的物理、表面和生物相容性的**可降解粘合聚合物的概念，该粘合聚合物可以与复合材料形成界面。该项目最终将为这种可降解的有机聚合物胶粘剂奠定基础。我们的临床和科学团队**致力于将新型粘合剂和目前的复合材料转化为实践，以**改善治疗和结果，减少并发症，改善那些**从CMF严重损伤和畸形中恢复的人的生活。

Deformities of the face and skull (craniomaxillofacial, CMF) can result from high impact**trauma, congenital malformations or tumours, which can lead to both functional disabilities**and physical disfigurement. Much like a shattered vase, the fractured CMF skeleton requires**alignment and stabilization of multiple pieces for successful reconstruction. In reconstructive**surgery, generally using plates and screws, complications occur in up to half of all cases. The**investigators have been working on the development of a composite material (Bone Tape)**for skull surgical reconstruction. The concept is a strong duct tape like device that can**adhere to bone and be used to reattach fractured pieces and hold them stable until they heal.**The properties of the composite offer a unique combination of strength, versatility and ease of**use, with the flexibility of tape allowing wrapping and bonding to the complex bone contours**found in the skeleton. The composite is also made of materials that will eventually (and**safely) resorb over time after the fracture has healed, leaving only the mended bones behind.**In developing this concept with industry, the clinicians used some commercial dental bone**cements that are not degradable and may generate residual particulate which the surgeons**would prefer to be resorbed and eliminated. Hence, there is a need for the conception of a**degradable adhesive polymer with appropriate physical, surface and biocompatibility**properties that can interphase with composites. This project will ultimately provide the**foundation for such a degradable organic polymer adhesive. Our clinical and scientific team is**committed to translating the novel adhesive along with current composites into practice, in**order to improve treatment and outcomes, with less complications and better lives for those**recovering from serious CMF injuries and deformities.