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Dissecting the molecular and cellular links between cilia, cGMP signaling, physiology and disease

Dissecting the molecular and cellular links between cilia, cGMP signaling, physiology and disease
剖析纤毛、cGMP 信号传导、生理学和疾病之间的分子和细胞联系
批准号:
181166
负责人:
Leroux Michel R
金额:
$39.08万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2009
资助国家:
加拿大
项目状态:
已结题
起止时间:
2009-03-01 至 2014-03-01

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英文摘要
Primary cilia are small hair-like cellular appendages that are found on most human cells and perform key roles in sensory perception, including smell, vision and hearing. Our recent studies have shed new insights into the physiological functions of cilia,
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Regulation of the intraflagellar transport pathway, a mutational hotspot required for cilium formation and maintenance
Cell biology of an evolutionarily conserved ciliary compartment essential for cellular signalling
Functional genomics of cilium formation and maintenance
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