Benchmarking the neurophysiology of human cortex models in vitro

体外人类皮质模型的神经生理学基准测试

• 批准号: FT230100138
• 负责人: Prof Cedric Bardy
• 金额: $ 78.9万
• 依托单位: Flinders University
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT230100138
• 关键词: Benchmarking; neurophysiology; human; cortex; models

This project aims to improve human brain models in vitro by developing an analytical tool benchmarking biophysical similarities to the adult human cortex. This project expects to generate new knowledge by testing for the first time the theory that integrating sensory-like inputs and awake/sleep-like cycles of electrical activity in vitro may complete the maturation of human brain organoid models. It will also generate new methods to simplify the analysis of multimodal path-clamping data (Patch-seq). Expected outcomes will facilitate research collaboration and the reproducibility of accurate experimental replicates of the human brain. This will provide significant benefits in the global race to understand human brain computation mechanisms.

该项目旨在通过开发一种分析工具，以成年人大脑皮层的生物物理相似性为基准，改进体外人脑模型。该项目预计将通过首次测试理论产生新的知识，该理论认为，在体外整合感觉类输入和清醒/睡眠类电活动周期可能会完成人脑类器官模型的成熟。它还将产生新的方法来简化多模式路径夹紧数据（Patch-seq）的分析。预期成果将促进研究合作和人类大脑准确实验复制的可重复性。这将为理解人类大脑计算机制的全球竞赛提供重大利益。