Impact of low dose radiation during late gestation on homeostatic control of metabolism and cellular function

妊娠晚期低剂量辐射对代谢和细胞功能稳态控制的影响

• 批准号: 494077-2016
• 负责人: Tai, TzeChun
• 金额: $ 7.74万
• 依托单位: Laurentian University of Sudbury
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=619117
• 关键词: Impact; low; dose; radiation; during

Living organisms are continually exposed to ionizing radiation. While high-dose exposure to ionizing radiation is known to cause harm, the impact of low-dose exposure remains contentious. Furthermore, the impact of exposure to ionizing radiation during late fetal development is poorly understood. Northern Ontario School of Medicine, Laurentian University, Lakeheahed University, McMaster University and Bruce Power have partnered together to study the fundamental biological effects of fetal exposure to low dose radiation on cellular development and function associated with stress and metabolism. This research will take a targeted approach in examining the physiological risks and/or benefits of low dose radiation exposure during late gestation, and examine the cellular and molecular mechanisms involved. Fundamental research will be performed to examine 3 key areas: 1) Effects of dose and timing of exposure to ionizing radiation during late gestation, 2) Role of reactive oxygen species (ROS) in initiating cellular changes, and 3) Potential adaptive and cellular responses to low dose radiation. The scientific knowledge gained will be beneficial in understanding the impact of environmental and occupational exposure to low dose radiation.

生物不断地暴露在电离辐射中。虽然高剂量暴露在电离辐射下是已知的危害，但低剂量暴露的影响仍然存在争议。此外，人们对胎儿发育后期暴露于电离辐射的影响知之甚少。北安大略省医学院、劳伦斯大学、莱克海德大学、麦克马斯特大学和布鲁斯·鲍尔合作研究了低剂量辐射对胎儿细胞发育和与应激和新陈代谢相关的功能的基本生物学影响。这项研究将采取有针对性的方法，研究妊娠晚期低剂量辐射暴露的生理风险和/或好处，并研究其中涉及的细胞和分子机制。基础研究将被用来研究3个关键领域：1)妊娠晚期电离辐射暴露的剂量和时间的影响，2)活性氧物种(ROS)在启动细胞变化中的作用，以及3)潜在的适应性和细胞对低剂量辐射的反应。所获得的科学知识将有助于理解低剂量辐射对环境和职业的影响。