Impact of low dose radiation during late gestation on homeostatic control of metabolism and cellular function

生物体不断地暴露在电离辐射下。虽然已知高剂量暴露于电离辐射会造成伤害，但低剂量暴露的影响仍有争议。此外，暴露于电离辐射对胎儿发育后期的影响尚不清楚。北安大略医学院、劳伦森大学、莱克黑德大学、麦克马斯特大学和布鲁斯·鲍尔合作研究了胎儿暴露在低剂量辐射下对细胞发育和与压力和代谢相关的功能的基本生物学影响。本研究将采取有针对性的方法来检查妊娠后期低剂量辐射暴露的生理风险和/或益处，并检查所涉及的细胞和分子机制。基础研究将进行3个关键领域的研究：1)妊娠后期电离辐射暴露剂量和时间的影响，2)活性氧（ROS）在启动细胞变化中的作用，以及3)低剂量辐射的潜在适应性和细胞反应。所获得的科学知识将有助于了解环境和职业暴露于低剂量辐射的影响。

Living organisms are continually exposed to ionizing radiation. While high-dose exposure to ionizing radiation is known to cause harm, the impact of low-dose exposure remains contentious. Furthermore, the impact of exposure to ionizing radiation during late fetal development is poorly understood. Northern Ontario School of Medicine, Laurentian University, Lakeheahed University, McMaster University and Bruce Power have partnered together to study the fundamental biological effects of fetal exposure to low dose radiation on cellular development and function associated with stress and metabolism. This research will take a targeted approach in examining the physiological risks and/or benefits of low dose radiation exposure during late gestation, and examine the cellular and molecular mechanisms involved. Fundamental research will be performed to examine 3 key areas: 1) Effects of dose and timing of exposure to ionizing radiation during late gestation, 2) Role of reactive oxygen species (ROS) in initiating cellular changes, and 3) Potential adaptive and cellular responses to low dose radiation. The scientific knowledge gained will be beneficial in understanding the impact of environmental and occupational exposure to low dose radiation.