Computational systems biology: understanding mammalian cell fates using genome-scale network models

计算系统生物学：使用基因组规模网络模型了解哺乳动物细胞的命运

• 批准号: DP110103384
• 负责人: Prof Mark Ragan
• 金额: $ 23.9万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP110103384
• 关键词: Computational; systems; biology; understanding; mammalian

Mutations can disrupt the cellular networks that control normal development, causing cells to develop abnormally including in ways that lead to cancer. The project will analyse genome sequences from more than 700 pancreatic cancers and matched controls to precisely map the causative trail from mutations to disrupted networks to altered cell development.

突变可以破坏控制正常发育的细胞网络，导致细胞异常发育，包括导致癌症的方式。该项目将分析来自700多个胰腺癌和匹配对照的基因组序列，以精确绘制从突变到破坏网络到改变细胞发育的致病线索。