Substrate stiffness and the role of actin in regulating chondrocyte dedifferentiation

基质硬度和肌动蛋白在调节软骨细胞去分化中的作用

• 批准号: RGPIN-2016-06088
• 负责人: Kandel, Rita
• 金额: $ 3.21万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=628784
• 关键词: Substrate; stiffness; role; actin; regulating

Articular cartilage covers the ends of bone facilitating joint movement and transfer of forces. Osteoarthritis is a disease of joints characterized by loss of the cartilage, and manifests as pain, stiffness and loss of range of motion disabling approximately 1 in 6 Canadians over the age of 15. Cartilage has little ability to repair when damaged. Current treatments alleviate symptoms only and do not stop disease progression so ultimately the damaged joint will require joint replacement with a prosthesis. These are made from metals and plastic and will ultimately fail. Clearly there is a great need for novel biological cell therapies to repair/replace the damaged cartilage that will fully restore joint function and health to normal.

关节软骨覆盖骨的末端，促进关节运动和力的传递。骨关节炎是一种关节疾病，其特征是软骨丧失，表现为疼痛、僵硬和活动范围丧失，约有1/6的15岁以上加拿大人致残。软骨在受损时几乎没有修复能力。目前的治疗只能缓解症状，不能阻止疾病的进展，因此最终受损的关节将需要用假体进行关节置换。这些都是由金属和塑料制成的，最终会失败。显然，非常需要新的生物细胞疗法来修复/替换受损的软骨，以完全恢复关节功能和健康。