Biological Finger Joint Replacement

生物指关节置换术

• 批准号: 523533-2018
• 负责人: Kandel, Rita
• 金额: $ 7.26万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Collaborative Health Research Projects
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=655043
• 关键词: Biological; Finger; Joint; Replacement

Osteoarthritis (OA) is the most common type of arthritis in Canada, and finger OA affects at**least 6.8% of individuals over the age of 26 years. In the absence of disease modifying**treatments, current therapeutic modalities are aimed at reducing pain. These treatments**alleviate symptoms but do not prevent the processes that result in the changes characteristic**of this disease. Failure of these treatments usually culminates in joint replacement surgery.**Current studies reporting outcomes of artificial finger joint replacements have highlighted the**high rate of failure and lack of efficacy in restoring hand function by such implants. We have**developed an alternative biological approach to joint repair that involves formation of a**personalized biological replacement designed for secure fixation by bone ingrowth while**presenting a surface lined by cartilage that will mimic the native joint form. In time as the bone**substitute component degrades and is replaced by natural tissues (bone), this replacement**part will allow for complete joint regeneration to the desired function.**The goal of this research proposal is to develop and evaluate a small joint biologic joint**replacement in a pre-clinical animal model. The aim is to design a joint replacement that can**be used to resurface a joint in the finger or wrist affected by either osteoarthritis or any**inflammatory arthritis such as psoriatic or rheumatoid arthritis.**With the results obtained from the proposed studies it will be possible to progress towards**translating our approach into a clinical treatment for people with hand arthritis.

骨关节炎（OA）是加拿大最常见的关节炎类型，手指OA影响至少6.8%的26岁以上的个体。在缺乏疾病修饰 ** 治疗的情况下，当前的治疗方式旨在减轻疼痛。这些治疗缓解了症状，但不能阻止导致这种疾病特征性变化的过程。这些治疗的失败通常在关节置换手术中达到高潮。**目前报告人工指关节置换术结果的研究强调了此类植入物在恢复手部功能方面的失败率很高且缺乏功效。我们已经开发了一种替代的关节修复生物学方法，包括形成一个个性化的生物替代品，旨在通过骨长入进行安全固定，同时提供一个模拟天然关节形式的软骨内衬表面。随着骨 ** 替代部件降解并被天然组织（骨）替代，该替代 ** 部件将允许关节完全再生至所需功能。**本研究计划的目标是在临床前动物模型中开发和评价小关节生物关节 ** 置换。其目的是设计一种关节置换术，可以用于重新修复受骨关节炎或任何炎症性关节炎（如银屑病或类风湿性关节炎）影响的手指或手腕关节。随着从拟议的研究中获得的结果，将有可能朝着 ** 将我们的方法转化为手部关节炎患者的临床治疗的方向发展。