Biological Finger Joint Replacement

生物指关节置换术

• 批准号: 523533-2018
• 负责人: Kandel, Rita
• 金额: $ 14.56万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Collaborative Health Research Projects
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=694182
• 关键词: Biological; Finger; Joint; Replacement

Osteoarthritis (OA) is the most common type of arthritis in Canada, and finger OA affects atleast 6.8% of individuals over the age of 26 years. In the absence of disease modifyingtreatments, current therapeutic modalities are aimed at reducing pain. These treatmentsalleviate symptoms but do not prevent the processes that result in the changes characteristicof this disease. Failure of these treatments usually culminates in joint replacement surgery.Current studies reporting outcomes of artificial finger joint replacements have highlighted thehigh rate of failure and lack of efficacy in restoring hand function by such implants. We havedeveloped an alternative biological approach to joint repair that involves formation of apersonalized biological replacement designed for secure fixation by bone ingrowth whilepresenting a surface lined by cartilage that will mimic the native joint form. In time as the bonesubstitute component degrades and is replaced by natural tissues (bone), this replacementpart will allow for complete joint regeneration to the desired function.The goal of this research proposal is to develop and evaluate a small joint biologic jointreplacement in a pre-clinical animal model. The aim is to design a joint replacement that canbe used to resurface a joint in the finger or wrist affected by either osteoarthritis or anyinflammatory arthritis such as psoriatic or rheumatoid arthritis.With the results obtained from the proposed studies it will be possible to progress towardstranslating our approach into a clinical treatment for people with hand arthritis.

骨关节炎（OA）是加拿大最常见的关节炎类型，手指OA影响至少6.8%的26岁以上的个体。在缺乏疾病改变治疗的情况下，目前的治疗方式旨在减轻疼痛。这些治疗可以减轻症状，但不能阻止导致这种疾病特征性变化的过程。这些治疗的失败通常在关节置换手术中达到高潮。目前报道人工手指关节置换结果的研究强调了这种植入物在恢复手功能方面的高失败率和缺乏疗效。我们已经开发了一种替代的生物学方法来修复关节，包括形成个性化的生物替代物，旨在通过骨长入进行安全固定，同时呈现出模拟天然关节形式的软骨内衬表面。随着骨替代物成分的降解并被天然组织（骨）取代，该替代部分将允许完全关节再生到所需的功能。本研究计划的目标是在临床前动物模型中开发和评估小关节生物关节置换术。我们的目标是设计一种关节置换术，可以用来重新修复受骨关节炎或任何炎症性关节炎（如银屑病或类风湿性关节炎）影响的手指或手腕关节。从拟议的研究中获得的结果将有可能将我们的方法转化为手部关节炎患者的临床治疗。