Meiotic spindle formation in C. elegans

线虫减数分裂纺锤体的形成

• 批准号: RGPIN-2017-04132
• 负责人: Mains, Paul
• 金额: $ 2.04万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=628949
• 关键词: Meiotic; spindle; formation; C.; elegans

Cells contain several types of internal protein "skeletons", termed the cytoskeletons. One type provides structural support, while another generates force, the cellular “bone” and “muscle”, respectively. We study how cells rearrange the cytoskeleton as embryos develop, where changes of the cytoskeleton can occur on the time scale of minutes so that cells and tissues can rapidly change their positions and shapes. Our approach is to find mutations in genes controlling these processes: by examining what goes wrong when the genes malfunction, we can infer the roles of the normal genes. Furthermore, we find sets of genes that together cooperate to carry out complex processes. Our work uses the nematode roundworm

细胞含有几种类型的内部蛋白质“骨架”，称为细胞骨架。一种类型提供结构支撑，而另一种类型产生力，分别是细胞“骨骼”和“肌肉”。我们研究细胞如何在胚胎发育过程中重新排列细胞骨架，细胞骨架的变化可以在几分钟的时间尺度上发生，这样细胞和组织就可以迅速改变它们的位置和形状。我们的方法是在控制这些过程的基因中找到突变：通过检查基因发生故障时出现的问题，我们可以推断正常基因的作用。此外，我们发现了一组基因，它们共同合作进行复杂的过程。我们的研究利用线虫