Hypoxia and the control of protein synthesis and homeostasis in Drosophila

果蝇缺氧与蛋白质合成和稳态的控制

• 批准号: RGPIN-2016-04544
• 负责人: Grewal, Savraj
• 金额: $ 3.93万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=628942
• 关键词: Hypoxia; control; protein; synthesis; homeostasis

Animals often live in conditions where environmental oxygen levels fluctuate As a result, they must coordinate their metabolism with changes in oxygen availability. In particular, upon oxygen deprivation, or hypoxia, animals need to alter their metabolism to limit energetically costly anabolic processes, maintain homeostasis and promote survival. Defects in this metabolic control can impair cell and tissue homeostasis and can lead to lethality.

动物通常生活在环境氧气水平波动的环境中，因此它们必须协调自己的新陈代谢和氧气供应的变化。特别是，在缺氧或缺氧的情况下，动物需要改变他们的新陈代谢，以限制耗费能量的合成代谢过程，保持动态平衡，促进生存。这种代谢控制的缺陷可能会破坏细胞和组织的动态平衡，并可能导致死亡。