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The molecular basis of meiotic crossover distribution

The molecular basis of meiotic crossover distribution
减数分裂交叉分布的分子基础
批准号:
RGPIN-2015-04266
负责人:
Rose, Ann
金额:
$2.48万
依托单位国家:
加拿大
项目类别:
Discovery Grants Program - Individual
财政年份:
2017
资助国家:
加拿大
项目状态:
已结题
起止时间:
2017-01-01 至 2018-12-31

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中文摘要
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英文摘要
My laboratory has identified the molecular basis of a gene responsible for establishing the distribution of crossover events in meiosis of Caenorhabditis elegans.  This is a significant result because the phenotype o rec-1 is unique in that it alters the position of the measured crossover event without any other measurable effects on frequency of recombination, fecundity or developmental processes.  A notable feature of the rec-1 gene is that it is poorly conserved at the level of primary sequence with other species, even though all species characterized to date show a meiotic pattern, which is another way of saying that the distribution of crossing over is not uniform along a chromosome.  There are a number of explanations for this apparent paradox; however the hypothesis that will be tested here is that rec-1 is an example of a
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The molecular basis of meiotic crossover distribution
  • 批准号:
    RGPIN-2015-04266
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $2.48万
  • 财政年份:
    2019
  • 负责人:
    Rose, Ann
  • 依托单位:
The molecular basis of meiotic crossover distribution
  • 批准号:
    RGPIN-2015-04266
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $2.48万
  • 财政年份:
    2018
  • 负责人:
    Rose, Ann
  • 依托单位:
The molecular basis of meiotic crossover distribution
  • 批准号:
    RGPIN-2015-04266
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $2.48万
  • 财政年份:
    2016
  • 负责人:
    Rose, Ann
  • 依托单位:
The molecular basis of meiotic crossover distribution
  • 批准号:
    RGPIN-2015-04266
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $2.48万
  • 财政年份:
    2015
  • 负责人:
    Rose, Ann
  • 依托单位:
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