A zebrafish model to investigate beta-cell functional maturation and heterogeneity

研究β细胞功能成熟和异质性的斑马鱼模型

• 批准号: RGPIN-2017-04106
• 负责人: Kieffer, Timothy
• 金额: $ 2.48万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629023
• 关键词: zebrafish; model; investigate; beta; cell

β-cells are a small population of highly specialized endocrine cells in the pancreas that produce insulin, a hormone required for survival and key to the proper regulation of energy homeostasis. While there is an increasing appreciation that there exists considerable β-cell heterogeneity, our understanding of the basis and significance of this heterogeneity, along with the factors guiding β-cell maturation, remain poorly understood.

β细胞是胰腺中一小部分高度特化的内分泌细胞，它们产生胰岛素，胰岛素是生存所需的激素，是适当调节能量稳态的关键。虽然越来越多的人认识到存在相当大的β细胞异质性，但我们对这种异质性的基础和意义沿着指导β细胞成熟的因素的理解仍然很少。