Discovering novel biochemical interactions between the complement and coagulation systems

发现补体和凝血系统之间新的生化相互作用

• 批准号: RGPIN-2017-03810
• 负责人: Conway, Edward
• 金额: $ 3.64万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629194
• 关键词: Discovering; novel; biochemical; interactions; between

Within the circulation, there exist two highly regulated systems that promote healing and prevent bleeding. One of these, the so-called coagulation system, is tightly controlled to achieve a critical balance between bleeding and clotting and to maintain the flow of blood. The other, the complement system, serves to rapidly and effectively dispose of invading infections and to prevent tissue and organ damage. Historically, the complex biochemical pathways featured in these two systems have been viewed as separate and non-intersecting. However, we and others groups of scientists now provide evidence to suggest that they do interact, which makes sense as both systems are initiated by the same triggers, under the same conditions. Moreover, many components (proteins) involved in coagulation and complement share a common evolutionary origin. It is likely, therefore, that these important biochemical pathways are co-ordinately controlled and highly interactive. Indeed, we have considerable data from our lab (published in the last 5 years with NSERC funding) that support such a hypothesis.

在血液循环中，存在两个高度调节的系统，促进愈合和防止出血。其中之一是所谓的凝血系统，它受到严格控制，以实现出血和凝血之间的关键平衡，并维持血液的流动。另一个是补体系统，用于快速有效地处理入侵的感染并防止组织和器官损伤。从历史上看，这两个系统中的复杂生化途径被视为独立和不相交的。然而，我们和其他科学家小组现在提供的证据表明，它们确实相互作用，这是有道理的，因为这两个系统是由相同的触发器在相同的条件下启动的。此外，参与凝血和补体的许多组分（蛋白质）具有共同的进化起源。因此，这些重要的生物化学途径很可能是协调控制的，并且是高度相互作用的。事实上，我们实验室的大量数据（在过去5年中由NSERC资助发表）支持这样的假设。