Discovering novel biochemical interactions between the complement and coagulation systems

发现补体和凝血系统之间新的生化相互作用

• 批准号: 418108-2012
• 负责人: Conway, Edward
• 金额: $ 2.91万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=573504
• 关键词: Discovering; novel; biochemical; interactions; between

Within the circulation, there exist systems that promote healing and prevent bleeding. One of these, the so-called coagulation system, is tightly controlled to achieve a critical balance between bleeding and clotting and to maintain the flow of blood. The other, the complement system, serves to rapidly and effectively dispose of invading infections and to prevent damage to our own tissue and organs. Historically, the complex biochemical pathways featured in these two systems have been viewed as separate and non-intersecting. However, there is increasing evidence to suggest that they do interact, which makes sense since both systems are initiated by the same triggers, under the same conditions. Moreover, many components (proteins) involved in coagulation and complement share a common evolutionary origin. It is likely, therefore, that these important biochemical pathways are co-ordinately controlled and highly interactive. Indeed, preliminary data from our lab support such a hypothesis. The long-term goal of our lab is to create new knowledge by systematically examining the biochemical interactions between the coagulation and complement systems, seeking to reveal entirely new information about the different involved components, their functions and the critical links between the biochemical pathways. The findings will potentially have a huge socio-economic impact as the identification of new pathways will lead to the need for new assays to measure changes in the blood during health and disease, and to the creation of industry and biotechnology for the development of new drugs that correct disease-associated imbalances in these systems.

在循环系统中，存在促进愈合和防止出血的系统。其中之一就是所谓的凝血系统，它被严格控制，以达到出血和凝血之间的关键平衡，并维持血液的流动。另一个是补体系统，它能迅速有效地处理入侵的感染，防止对我们自己的组织和器官造成损害。历史上，这两个系统中复杂的生化途径被认为是分开的和不相交的。然而，越来越多的证据表明它们确实相互作用，这是有道理的，因为两个系统都是在相同的条件下由相同的触发因素启动的。此外，许多参与凝血和补体的成分（蛋白质）具有共同的进化起源。因此，很可能这些重要的生化途径是协调控制和高度互动的。事实上，我们实验室的初步数据支持这样的假设。