Unveiling the molecular mechanisms of vesicular trafficking, membrane fusion, and intravesicular acidification

揭示囊泡运输、膜融合和囊泡内酸化的分子机制

• 批准号: RGPIN-2015-06438
• 负责人: Sugita, Shuzo
• 金额: $ 2.77万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629242
• 关键词: Unveiling; molecular; mechanisms; vesicular; trafficking

In order for a complex system of organs and tissues that compose an organism to maintain homeostasis and co-ordinate the intricate set of activities that are vital for its survival and well-being, the cells that comprise these organs and tissues must be able to communicate with and regulate each other. It is the secretory vesicles within these cells that house the vast array of contents that cells use to achieve this cell-to-cell communication. Thus, the regulation of these processes is an important area of inquiry in the field of fundamental cellular biology. Interestingly, these processes have been shown to be strongly influenced by the acidification of the intravesicular compartment.

为了使组成有机体的器官和组织的复杂系统保持体内平衡并协调对其生存和健康至关重要的复杂活动，组成这些器官和组织的细胞必须能够相互沟通和调节。正是这些细胞内的分泌囊泡容纳了大量的内容物，细胞使用这些内容物来实现这种细胞与细胞的交流。因此，这些过程的调节是基础细胞生物学领域的一个重要研究领域。有趣的是，这些过程已被证明是强烈影响的囊内室的酸化。