Roles for the exocyst complex in vesicular trafficking

外囊复合体在囊泡运输中的作用

• 批准号: 298461-2009
• 负责人: Sugita, Shuzo
• 金额: $ 2.7万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=498139
• 关键词: Roles; exocyst; complex; vesicular; trafficking

Secretory vesicles store important chemical substances such as transmitters, hormones and inflammatory substances and release them through exocytosis at the plasma membrane. Exocytosis in mammalian cells is tightly controlled by intracellular signals including calcium and GTP. Supported by the funding from NSERC, we have identified the critical roles played by a small GTPase protein, Ral, as well as the exocyst protein complex (composed of 8 proteins) in GTP-dependent exocytosis.

分泌囊泡储存重要的化学物质，如递质、激素和炎性物质，并通过胞吐作用在质膜上释放它们。哺乳动物细胞中的胞吐作用受到细胞内信号（包括钙和鸟苷酸）的严格控制。在NSERC的资助下，我们已经确定了一个小的GTP酶蛋白Ral以及外囊蛋白复合物（由8种蛋白组成）在GTP依赖性胞吐中发挥的关键作用。