Regulation of Skeletal Development by Sphingomyelin Phosphodiesterase 3

鞘磷脂磷酸二酯酶 3 对骨骼发育的调节

• 批准号: RGPIN-2017-06881
• 负责人: Murshed, Monzur
• 金额: $ 2.48万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629338
• 关键词: Regulation; Skeletal; Development; Sphingomyelin; Phosphodiesterase

For a long time, sphingolipids were considered as inert structural molecules. This view, however, has radically changed in recent years as sphingolipids are now recognized as important metabolites regulating cell growth, death, differentiation and stress responses. The identification of sphingomyelin phosphodiesterase 3 (SMPD3; also known as neutral sphingomyelinase 2) as a novel regulator of skeletal development and the recently developed animal models lacking or overexpressing this enzyme in a spatiotemporal manner have created exciting opportunities to further understand the cellular events leading to endochondral bone development.

长期以来，鞘脂被认为是惰性结构分子。然而，这种观点近年来发生了根本性的改变，因为鞘脂现在被认为是调节细胞生长、死亡、分化和应激反应的重要代谢物。鞘磷脂磷酸二酯酶 3（SMPD3；也称为中性鞘磷脂酶 2）作为骨骼发育的新型调节剂，以及最近开发的以时空方式缺乏或过度表达该酶的动物模型，为进一步了解导致软骨内骨发育的细胞事件创造了令人兴奋的机会。