Protein-mineral interactions at the organic-inorganic interface in biominerals

生物矿物质中有机-无机界面的蛋白质-矿物质相互作用

• 批准号: RGPIN-2016-05031
• 负责人: McKee, Marc
• 金额: $ 2.4万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629382
• 关键词: Protein; mineral; interactions; organic; inorganic

Bones, teeth, otoconia, eggshells, snail and sea shells, corals and many other biomineralized structures in the plant and animal kingdoms arise from synergistic interactions between co-existing organic (usually proteins) and inorganic mineral phases. These composites have specialized properties, and hierarchically organized supramolecular assemblies that provide a framework for biomineralization. Negatively charged proteins may attain regulatory chemical complementarity by binding to mineral calcium at the organic-inorganic interface − a mechanism to influence crystal growth processes. It is hypothesized that the molecular precision of such organic-inorganic interfacial interactions regulates crystal growth. My biomineralization research program focuses on specific proteins/peptides (notably osteopontin) that regulate mineral growth.

在动植物王国中，骨骼、牙齿、耳石、蛋壳、蜗牛和海贝、珊瑚和许多其他生物矿化结构来自共存的有机(通常是蛋白质)和无机矿物相之间的协同作用。这些复合材料具有特殊的性质，并有层次地组织超分子组装，为生物矿化提供了一个框架。带负电荷的蛋白质可能通过与有机-无机界面上的矿物质钙结合来实现调节化学互补，这是一种影响晶体生长过程的机制。据推测，这种有机-无机界面相互作用的分子精度决定了晶体的生长。我的生物矿化研究项目专注于调节矿物质生长的特定蛋白质/多肽(特别是骨桥蛋白)。