Characterization of new VAV2-binding proteins.

新 VAV2 结合蛋白的表征。

• 批准号: RGPIN-2017-05154
• 负责人: Marignani, Paola
• 金额: $ 1.89万
• 依托单位: Dalhousie University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629406
• 关键词: Characterization; new; VAV2; binding; proteins.

The reorganization of cytoskeleton is a highly conserved molecular process that is required by single and multi-cell organisms to survive. The cytoskeleton is a complex structure comprised of hundreds of molecules that work synchronously to maintain the infrastructure of the cell or to move cells in response to stimuli. Although there are hundreds of molecules involved in the regulation of cell migration, our focus is on the phylogenetically conserved Vav family of guanine nucleotide exchange factors (GEFs)

细胞骨架的重组是单细胞和多细胞生物生存所必需的高度保守的分子过程。细胞骨架是由数百个分子组成的复杂结构，这些分子同步工作以维持细胞的基础结构或响应刺激而移动细胞。虽然有数百种分子参与细胞迁移的调控，但我们的重点是在遗传上保守的鸟嘌呤核苷酸交换因子（GEFs）的Vav家族