Characterization of new VAV2-binding proteins.

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The reorganization of cytoskeleton is a highly conserved molecular process that is required by single and multi-cell organisms to survive. The cytoskeleton is a complex structure comprised of hundreds of molecules that work synchronously to maintain the infrastructure of the cell or to move cells in response to stimuli. Although there are hundreds of molecules involved in the regulation of cell migration, our focus is on the phylogenetically conserved Vav family of guanine nucleotide exchange factors (GEFs)