The regulation of adipose-derived MIF: A novel secretory function of preadipocytes mediated by PAR2

脂肪源性 MIF 的调节：PAR2 介导的前脂肪细胞的新型分泌功能

• 批准号: RGPIN-2017-04542
• 负责人: Qi, Dake
• 金额: $ 1.89万
• 依托单位: Memorial University of Newfoundland
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629501
• 关键词: regulation; adipose; derived; MIF; novel

Adipose tissue is commonly considered as an organ system responsible for energy storage, temperature regulation and wound healing, yet it is also an important endocrine organ which secrets hormones and inflammatory factors that mediate metabolic process in mammals. The molecular mechanisms in regulating the secretory function of adipose tissue are largely unknown and revealing these mechanisms will have important implications for animal physiology and biochemistry. Thus, our long-term goal is to elucidate how adipose tissue orchestrates whole-body metabolism as an endocrine organ.

脂肪组织通常被认为是负责能量储存、温度调节和伤口愈合的器官系统，但它也是重要的内分泌器官，分泌激素和炎症因子，介导哺乳动物的代谢过程。调节脂肪组织分泌功能的分子机制在很大程度上尚不清楚，揭示这些机制将对动物生理学和生物化学产生重要影响。因此，我们的长期目标是阐明脂肪组织如何作为内分泌器官协调全身代谢。