The expression and function of stress proteins in uterine smooth muscle during pregnancy

妊娠期子宫平滑肌应激蛋白的表达及功能

• 批准号: RGPIN-2017-04951
• 负责人: MacPhee, Daniel
• 金额: $ 2.04万
• 依托单位: University of Saskatchewan
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629504
• 关键词: expression; function; stress; proteins; uterine

The uterus is a female organ that houses the developing fetus during pregnancy. This organ contains a smooth muscle component named the myometrium and during pregnancy it goes through a program of differentiation and adaptation at the molecular and cellular level. In parallel with this myometrial programming, the myometrium and other tissues also undergo transformation of immune system components. The consequence of both of these processes is the production of uterine tissue that can generate coordinated and powerful contractions (labour) to ensure the timely delivery of a term fetus whose organs are sufficiently mature for survival outside the uterus. Unfortunately, we still do not clearly understand what controls myometrial programming and immune transformation as well as their coordination during pregnancy.

子宫是女性器官，在怀孕期间容纳发育中的胎儿。这个器官包含一个名为子宫肌层的平滑肌成分，在怀孕期间，它在分子和细胞水平上经历了一个分化和适应的程序。与这种子宫肌层编程并行，子宫肌层和其他组织也经历免疫系统组分的转化。这两个过程的结果是子宫组织的产生，可以产生协调和强大的收缩（分娩），以确保足月胎儿的及时分娩，其器官足够成熟，可以在子宫外存活。不幸的是，我们仍然不清楚是什么控制着子宫肌层编程和免疫转化以及它们在怀孕期间的协调。