Mechanisms of sensory transduction and sensory information coding

感觉转导和感觉信息编码机制

• 批准号: RGPIN-2016-03712
• 负责人: French, Andrew
• 金额: $ 2.4万
• 依托单位: Dalhousie University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629607
• 关键词: Mechanisms; sensory; transduction; information; coding

Detection of external and internal physical and chemical signals are essential processes for all living things. Our research is aimed at discovering fundamental mechanisms of three important sensory modalities, mechanosensation, vision and olfaction. Understanding how these senses work would have wide implications in fields such as medicine, agriculture and robotics. We use a combination of experimental approaches that include electrical recordings, molecular biology, optical imaging and bioinformatics to discover how primary sensory nerve cells detect and process sensory signals. We are also interested in how sensory transduction mechanisms are adapted to different environments and lifestyles, if they are modulated by neurochemicals, and what kinds of information about the detected signals are transmitted to the brain.

检测外部和内部的物理和化学信号是所有生物的基本过程。我们的研究旨在发现机械感觉、视觉和嗅觉这三种重要感觉方式的基本机制。了解这些感官的工作原理将对医学、农业和机器人等领域产生广泛影响。我们结合使用电记录、分子生物学、光学成像和生物信息学等实验方法来发现初级感觉神经细胞如何检测和处理感觉信号。我们还感兴趣的是，感觉转导机制如何适应不同的环境和生活方式，如果它们受到神经化学物质的调节，以及有关检测到的信号的哪些信息被传输到大脑。