Measuring the effect of environmental stress on checkpoint, genome instability and survival

测量环境压力对检查点、基因组不稳定性和生存的影响

• 批准号: RGPIN-2015-04405
• 负责人: Sabatinos, Sarah
• 金额: $ 2.33万
• 依托单位: Ryerson University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629626
• 关键词: Measuring; effect; environmental; stress; checkpoint

Cells have a remarkable ability to survive toxic stress. Different kinds of stress –harmful drugs, UV light, heavy metals like mercury– have different outcomes. My work examines DNA damaging drugs. DNA determines how we grow, change, and how our children develop. When DNA is damaged by a drug, the cell activates a pathway that STOPS its growth. By STOPPING growth, a cell can assess damage, repair it and then resume healthy division. These STOP pathways are called “checkpoints.” I am interested in how checkpoints work and why they fail. A faulty checkpoint causes massive problems including DNA rearrangements and death. Many cancers are a direct result of checkpoint failures.

细胞具有在毒性压力下存活的非凡能力。不同种类的压力--有害药物、紫外线、汞等重金属--会产生不同的结果。我的工作是研究破坏DNA的药物。DNA决定了我们如何成长，如何改变，以及我们的孩子如何发展。当DNA被药物破坏时，细胞会激活一条阻止其生长的途径。通过停止生长，细胞可以评估损伤，修复它，然后恢复健康的分裂。这些STOP路径被称为“检查点”。我对检查点是如何工作的以及它们为什么会失败很感兴趣。一个错误的检查点会导致大量的问题，包括DNA重排和死亡。许多癌症是检查点失败的直接结果。