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Lab2Market NSERC I2I Market Assessment of positive pombe: engineering anti-depressant molecules in fission yeast

Lab2Market NSERC I2I 阳性裂殖酵母的市场评估：在裂殖酵母中设计抗抑郁分子

基本信息

批准号：
571247-2022
负责人：
Sabatinos, Sarah
金额：
$ 1.46万
依托单位：
Ryerson University
依托单位国家：
加拿大
项目类别：
Idea to Innovation
财政年份：
2021
资助国家：
加拿大
起止时间：
2021-01-01 至 2022-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=729101
关键词：
Lab2Market NSERC I2I Market Assessment

项目摘要

We are developing a synthetic biology platform for biologically important molecule production in fission yeast (Schizosaccharomyces pombe). This Lab2Market I2I Market Assessment program allows us to assess our technology and offering within the current market. We examine our primary research/technology development, expanding on a general customer-based survey in the Lab2Market Mitacs program. Our initial molecule of interest is psilocybin. Psilocybin is a potential compound to treat depression, addiction, and anxiety. It would be an alternative to other pharmaceutical drugs. Psilocybin is related to naturally occurring molecules found in cells, and results from a chemical conversion in Psylocibe mushrooms. However, extracting and purifying psilocybin from mushrooms leads to variable products, and large-scale extraction is not possible. Chemical synthesis is possible but expensive. We will use enzymes from the mushroom and express them in fission yeast cells. These yeast cultures provide an opportunity for consistent and high- yield synthesis from starting media. Long-term, we eliminate the time, space, and labor-intensive method of harvesting mushrooms, and the cost-intensive method of psilocybin chemical synthesis from expensive starting materials. In the future, we expect that this will allow us to generate other related compounds effective in an optimized synthetic biology platform, and with linked market considerations.

我们正在开发一个合成生物学平台，用于在裂殖酵母（裂殖酵母）中生产生物学重要分子。这个Lab 2 Market I2 I市场评估计划使我们能够评估我们的技术和产品在当前市场。我们研究我们的主要研究/技术开发，扩大在Lab 2 Market Mitacs计划中基于客户的一般调查。我们最初感兴趣的分子是裸盖菇素。裸盖菇素是一种治疗抑郁症、成瘾和焦虑的潜在化合物。它将成为其他药物的替代品。裸盖菇素与细胞中天然存在的分子有关，是由Psylocibe蘑菇中的化学转化产生的。然而，从蘑菇中提取和纯化裸盖菇素会导致可变的产品，并且不可能进行大规模提取。化学合成是可能的，但昂贵。我们将使用蘑菇中的酶并在裂变酵母细胞中表达它们。这些酵母培养物提供了从起始培养基进行一致和高产合成的机会。从长远来看，我们消除了收获蘑菇的时间，空间和劳动密集型方法，以及从昂贵的起始材料进行裸盖菇素化学合成的成本密集型方法。在未来，我们预计这将使我们能够在优化的合成生物学平台上产生其他有效的相关化合物，并考虑到相关的市场因素。