The Population Biology of Vibrio cholerae

霍乱弧菌的群体生物学

• 批准号: RGPIN-2015-04015
• 负责人: Boucher, Yan
• 金额: $ 2.19万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629708
• 关键词: Population; Biology; Vibrio; cholerae

Although population biology is a well-developed science for animals and plants, it is still in its infancy for microbes. Most of the foundational work for population “micro” biology has been performed with human pathogens, which are not representative of environmental bacteria. Unfortunately, most bacteria from the wild are hard to culture, limiting our ability to get enough individuals to study population-level phenomena for microbes. Culture-independent methods, such as metagenomics and small ribosomal subunit gene sequencing, have also had limited success, because of their lack of resolution at the species level or below.

尽管种群生物学在动物和植物方面已经是一门成熟的科学，但对于微生物来说，它仍然处于起步阶段。大多数群体“微”生物学的基础工作都是用人类病原体进行的，这些病原体并不代表环境细菌。不幸的是，大多数野生细菌很难培养，这限制了我们获得足够多的个体来研究微生物群体水平现象的能力。不依赖培养的方法，如宏基因组学和核糖体小亚基基因测序，也取得了有限的成功，因为它们缺乏物种水平或以下的分辨率。