Finding the missing link in the life cycle of pandemic generating Vibrio cholerae O1

寻找产生大流行的霍乱弧菌 O1 生命周期中缺失的环节

• 批准号: RGPIN-2020-04422
• 负责人: Boucher, Yan
• 金额: $ 3.06万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=744704
• 关键词: Finding; missing; link; life; cycle

The bacterium Vibrio cholerae is an aquatic microbe responsible for the often-lethal diarrheal disease cholera, which affects hundreds of thousands of people every year. Only a specific lineage of this species, often known as O1/O139 for the antigens displayed on their surface, can cause the disease. Despite decades of studying this bacterium, we are still struggling to explain how yearly outbreaks start in areas where it is found. A recent cholera outbreak resulting from the consumption of herring eggs on the coast of Vancouver island also raises concerns as to whether climate change is expanding the range of this disease, normally restricted to warmer climates. We have recently found that our difficulty in understanding the start of outbreaks was because we studied the entire Vibrio cholerae species, not individual lineages. Indeed, each lineage of this species seems to have its own ecological characteristics, such as living at various salt concentrations, temperatures, or associated with different types of particles or hosts. Here we aim to define the environmental factors that specifically favor the pathogenic Vibrio cholerae O1/O139 lineage. This would allow us to better understand its dispersal and blooming in aquatic environments, so that we can predict outbreaks more accurately and identify the implications of global warming for the range of this disease.

霍乱弧菌（Vibrio cholesterol）是一种水生微生物，通常会导致致命的霍乱，每年影响数十万人。只有这种物种的特定谱系，通常被称为O 1/O 139，因为它们表面上显示的抗原，可以引起这种疾病。尽管对这种细菌进行了数十年的研究，但我们仍然难以解释每年的疫情是如何在发现这种细菌的地区爆发的。最近，温哥华岛海岸因食用鲱鱼卵而爆发的霍乱疫情也引发了人们的担忧，即气候变化是否正在扩大这种疾病的范围，通常只限于温暖的气候。 我们最近发现，我们在理解暴发开始时的困难是因为我们研究了整个霍乱弧菌物种，而不是单个谱系。事实上，该物种的每个谱系似乎都有自己的生态特征，例如生活在不同的盐浓度，温度下，或与不同类型的颗粒或宿主相关。在这里，我们的目标是确定环境因素，特别有利于致病性霍乱弧菌O 1/O 139谱系。这将使我们能够更好地了解它在水生环境中的传播和繁殖，以便我们能够更准确地预测疫情，并确定全球变暖对这种疾病范围的影响。