Antimicrobial peptide resistance mechanisms in adherent-invasive Escherichia coli

粘附侵袭性大肠杆菌的抗菌肽耐药机制

• 批准号: RGPIN-2015-04679
• 负责人: McPhee, Joseph
• 金额: $ 2.33万
• 依托单位: Ryerson University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629713
• 关键词: Antimicrobial; peptide; resistance; mechanisms; adherent

In order to adapt to their environment, bacteria must convert environmental signals into an appropriate response. Understanding both the signals involved and the mechanisms by which they are incorporated into an observed phenotype allows us to develop strategies to intervene in these critical processes. In this proposal, we describe a research program that will allow us to understand how diverse strains of host-adapted adherent-invasive

为了适应环境，细菌必须将环境信号转化为适当的反应。了解所涉及的信号和它们被纳入观察到的表型的机制，使我们能够制定干预这些关键过程的策略。在这个建议中，我们描述了一个研究计划，这将使我们能够了解不同的菌株如何适应宿主的粘附-侵袭性