Discovery and application of regulatory mechanisms controlling SNF1 kinase dependent stress resistance

控制SNF1激酶依赖性应激抵抗的调控机制的发现和应用

• 批准号: RGPIN-2016-04575
• 负责人: Arnason, Terra
• 金额: $ 2.26万
• 依托单位: University of Saskatchewan
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629953
• 关键词: Discovery; application; regulatory; mechanisms; controlling

Global weather extremes and population pressures on world food supply, combined with decreasing arable land availability and declining ocean stocks, underscore the urgency in understanding how to enhance food production in suboptimal environments. Critical to stress resistance is the SNF1 kinase enzyme complex. Our earlier work with yeast cells showed that SNF1 kinase activity is important in promoting the cells’ responses to environmental stress and lack of nutrients, helping them to adapt to poor conditions. Conserved versions of SNF1 enzymes are found in all plants and animals. Understanding how their action is regulated genetically, and how it helps organisms to survive, offers the potential to develop crops and livestock that are better adapted to thrive in harsh environments.

全球极端天气和人口对世界粮食供应的压力，再加上可耕地供应减少和海洋资源减少，突显了了解如何在次优环境中提高粮食生产的紧迫性。对抗逆性至关重要的是SNF1激酶复合体。我们早期对酵母细胞的研究表明，SNF1激酶活性在促进细胞对环境压力和缺乏营养的反应方面非常重要，帮助它们适应恶劣的条件。SNF1酶的保守版本存在于所有动植物中。了解它们的行为是如何受到基因调控的，以及它如何帮助生物生存，为开发更好地适应恶劣环境的作物和牲畜提供了潜力。