Discovery and application of regulatory mechanisms controlling SNF1 kinase dependent stress resistance

全球极端天气和人口对世界粮食供应的压力，加上可耕地减少和海洋资源减少，突出表明迫切需要了解如何在次优环境中提高粮食生产。SNF1激酶复合物是抗逆的关键。我们早期对酵母细胞的研究表明，SNF1激酶活性在促进细胞对环境压力和营养缺乏的反应方面非常重要，有助于它们适应恶劣的条件。SNF1酶的保守版本存在于所有植物和动物中。了解它们的行为如何在基因上受到调节，以及它如何帮助生物体生存，可以开发出更适合在恶劣环境中茁壮成长的作物和牲畜。

Global weather extremes and population pressures on world food supply, combined with decreasing arable land availability and declining ocean stocks, underscore the urgency in understanding how to enhance food production in suboptimal environments. Critical to stress resistance is the SNF1 kinase enzyme complex. Our earlier work with yeast cells showed that SNF1 kinase activity is important in promoting the cells’ responses to environmental stress and lack of nutrients, helping them to adapt to poor conditions. Conserved versions of SNF1 enzymes are found in all plants and animals. Understanding how their action is regulated genetically, and how it helps organisms to survive, offers the potential to develop crops and livestock that are better adapted to thrive in harsh environments.