Working Mechanisms of Ribbon Synapses in Cochlea

耳蜗带状突触的工作机制

• 批准号: RGPIN-2017-04493
• 负责人: Wang, Jian
• 金额: $ 1.89万
• 依托单位: Dalhousie University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630108
• 关键词: Working; Mechanisms; Ribbon; Synapses; Cochlea

Inner hair cells (IHCs) in the cochlea synapse with type I primary auditory neurons (spiral ganglion neurons, SGNs), providing the main information pathway to auditory brain. This synapse are characterized by their pre-synaptic ribbon structure, and therefore called ribbon synapses. It is known that the specific structure and molecular composition in the presynaptic compartment are responsible for the quick and long-lasting responses to sound. However, little detail is known how the ribbon synapses in cochlea play such roles.

耳蜗区内毛细胞(IHCs)与I型初级听神经元(螺旋神经节神经元，SGN)形成突触，为听性脑提供主要信息通路。这种突触的特征是它们的突触前带状结构，因此被称为带状突触。众所周知，突触前隔区的特定结构和分子组成是导致对声音快速而持久的反应的原因。然而，人们对耳蜗区的带状突触如何扮演这样的角色知之甚少。