Changes of temporal coding in inferior colliculus and auditory cortex of the guinea pig after cochlear lesion

豚鼠耳蜗损伤后下丘和听觉皮层颞叶编码的变化

• 批准号: 250088-2007
• 负责人: Wang, Jian
• 金额: $ 1.74万
• 依托单位: Dalhousie University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=479475
• 关键词: Changes; temporal; coding; inferior; colliculus

This project will investigate the changes of temporal coding of neurons in low frequency region of inferior colliculus (IC) and auditory cortex (AC) after damage is created in high frequency region in cochleae (the auditory part of inner ears). Previous studies have suggested that the impact of cochlear lesion is not confined to the auditory peripheral, but extends to central auditory system (CAS) as well. Consequently, plastic changes in the processing of frequency, intensity as well as temporal features of sound have been associated in CAS with sensorineural hearing loss (SNHL). However, a comprehensive understanding in temporal processing problem due to SNHL is not available. Specifically, it is not clear whether and how high-frequency SNHL, the most common pattern of SNHL for the elderly, will produce "off-channel" impact on the temporal processing in the low-frequency region as it has been demonstrated in intensity and frequency coding. This will be the focus of the proposed study.

本课题旨在研究耳蜗高频区（内耳的听觉部分）损伤后，下丘（IC）和听皮层（AC）低频区神经元时间编码的变化。以往的研究表明，耳蜗病变的影响不仅限于听觉外周，而且还扩展到中枢听觉系统（CAS）。因此，在CAS中，声音的频率、强度以及时间特征的处理中的塑性变化与感音神经性听力损失（SNHL）相关。然而，由于SNHL的时间处理问题的全面理解是不可用的。具体而言，目前尚不清楚是否以及如何高频SNHL，SNHL的老年人最常见的模式，将产生“信道外”的影响，在低频区域的时间处理，因为它已被证明在强度和频率编码。这将是拟议研究的重点。