The relationship between genome, epigenome, and performance in long-live plants

长寿植物基因组、表观基因组和性能之间的关系

• 批准号: RGPIN-2017-06552
• 负责人: Braeutigam, Katharina
• 金额: $ 2.19万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630325
• 关键词: relationship; between; genome; epigenome; performance

Immobile organisms cannot simply evade unfavorable, stressful, conditions. They can, however, show a remarkable flexibility under varying environmental conditions that ensures growth and survival. Especially long-lived plants like trees exhibit such an astonishing flexibility. In addition to a genetic component, epigenetic mechanisms play key roles in contributing to this “phenotypic plasticity”. Epigenetics, literally “above genetics”, refers to the study of changes in gene function that can be induced in response internal or external signals, that can be heritable across cell division but that do not result from changes in an organism’s DNA. Thus, epigenetic marks can provide an additional layer of plasticity at the molecular level. The goal of my research is to investigate how remodeling of the epigenome relates to stress “memory” and life cycle characteristics in long-lived plants. In the next five years, my lab will address the following three interconnected research objectives, using the poplar as model for tree species.

不能移动的有机体不能简单地逃避不利的、有压力的条件。然而，它们可以在不同的环境条件下表现出非凡的灵活性，以确保生长和生存。尤其是像树木这样的长寿植物表现出如此惊人的灵活性。除了遗传因素外，表观遗传机制在这种“表型可塑性”中起着关键作用。表观遗传学，字面意思是“高于遗传学”，是指研究在响应内部或外部信号时可以诱导的基因功能变化，这些信号可以在细胞分裂过程中遗传，但不是由于生物体DNA的变化而导致的。因此，表观遗传标记可以在分子水平上提供额外的可塑性。我的研究目标是调查表观基因组的重塑如何与长寿命植物的逆境“记忆”和生命周期特征有关。在接下来的五年里，我的实验室将使用杨树作为树种的模型，解决以下三个相互关联的研究目标。