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Deciphering the mechanisms of synaptic dysfunction in a genetic model of spinal muscular atrophy

Deciphering the mechanisms of synaptic dysfunction in a genetic model of spinal muscular atrophy
破译脊髓性肌萎缩症遗传模型中突触功能障碍的机制
批准号：
369971
负责人：
Patten Kessen
金额：
$45.7万
依托单位：
INRS-Institut Armand-Frappier (Laval)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2017
资助国家：
加拿大
项目状态：
已结题
起止时间：
2017-09-01 至 2022-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=369971&lang=en
关键词：
Development Electrophysiology Motor Neuron Diseases Rna Binding Protein Rna Sequencing Spinal Muscular Atrophy Zebrafish

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英文摘要
Spinal muscular atrophy (SMA) is a devastating neurodegenerative disease characterized by death of motoneurons innervating skeletal muscle fibers. It is the leading genetic cause of infant mortality, but no effective treatment is currently available. SMA
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