Define Interneuron Subpopulations in the Mouse Spinal Cord during Development

定义发育过程中小鼠脊髓的中间神经元亚群

• 批准号: RGPIN-2016-04880
• 负责人: Zhang, Ying
• 金额: $ 2.04万
• 依托单位: Dalhousie University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630519
• 关键词: Define; Interneuron; Subpopulations; Mouse; Spinal

Precise organization of neural circuits ensures proper functioning of the central nervous system (CNS). Assembly of these circuits requires correct specification of neuronal populations defined during development. One goal in my research is to understand developmental processes underlying formation of functional groups of spinal neurons. Different progenitor domains in the embryonic spinal cord give rise to the motoneurons (MNs) and different interneuron (IN) classes, each with a unique molecular profile. Distinct types of spinal INs emerge from these progenitor domains, and, as recently revealed, some undergo further subdivision to form heterogeneous populations. As yet, however, little is known about molecular mechanisms that govern such subdivision.

神经回路的精确组织确保中枢神经系统（CNS）的正常功能。这些回路的组装需要在发育过程中定义的神经元群体的正确规格。 我的研究目标之一是了解脊髓神经元功能群形成的发育过程。胚胎脊髓中不同的祖细胞结构域产生了运动神经元（MN）和不同的中间神经元（IN）类，每个类都具有独特的分子特征。不同类型的脊髓神经元出现从这些祖域，而且，最近发现，一些进行进一步细分，形成异质群体。然而，到目前为止，人们对这种细分的分子机制知之甚少。