Hippocampal cortical interactions and the extraction of knowledge from episodic memory

海马皮层相互作用和从情景记忆中提取知识

• 批准号: RGPIN-2017-03857
• 负责人: McNaughton, Bruce
• 金额: $ 6.56万
• 依托单位: University of Lethbridge
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630583
• 关键词: Hippocampal; cortical; interactions; extraction; knowledge

My research program focusses on the neuro-computational basis of memory and the dynamic interactions among neuronal populations that lead to the brain’s ability to create an adaptive model of its. Over the past 35 years, I have made major contributions to understanding central synaptic plasticity mechanisms, spatial information processing, cortico-hippocampal interactions and memory consolidation, and significantly advanced technologies for systems neuroscience investigation. In the course of this work I have provided outstanding training to 33 graduate students, and 37 postdocs, most of whom are pursuing research careers at major universities. Over the next 5 years, my overall programme (including other support) will provide training for at least 4 undergrads, 10 graduates and 7 postdocs, as we continue to study the impact of hippocampal back projections to the neocortex on neural coding and neural plasticity in that structure. Understanding this impact is key to understanding why, in the absence of a functional hippocampus, the neocortex is unable to form new memories or to extract general knowledge from experience efficiently. It is also key to understanding a mode of computational knowledge acquisition and representation that may have far reaching impacts on information and computer technology.

我的研究项目主要集中在记忆的神经计算基础和神经元群体之间的动态相互作用，这些相互作用导致大脑能够创建其自适应模型。在过去的35年里，我在理解中枢突触可塑性机制、空间信息处理、皮质-海马相互作用和记忆巩固以及系统神经科学研究的先进技术方面做出了重大贡献。在这项工作的过程中，我为33名研究生和37名博士后提供了出色的培训，他们中的大多数人都在主要大学从事研究工作。在接下来的5年里，我的整体计划（包括其他支持）将为至少4名本科生，10名研究生和7名博士后提供培训，因为我们将继续研究海马回投射到新皮层对该结构中的神经编码和神经可塑性的影响。理解这种影响是理解为什么在没有功能性海马体的情况下，新皮层无法形成新记忆或从经验中有效提取一般知识的关键。它也是理解计算知识获取和表示模式的关键，可能对信息和计算机技术产生深远影响。