Hippocampal cortical interactions and the extraction of knowledge from episodic memory
海马皮层相互作用和从情景记忆中提取知识
基本信息
- 批准号:RGPIN-2017-03857
- 负责人:
- 金额:$ 6.56万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2022
- 资助国家:加拿大
- 起止时间:2022-01-01 至 2023-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
My research program focusses on the neuro-computational basis of memory and the dynamic interactions among neuronal populations that lead to the brain's ability to create an adaptive model of its. Over the past 35 years, I have made major contributions to understanding central synaptic plasticity mechanisms, spatial information processing, cortico-hippocampal interactions and memory consolidation, and significantly advanced technologies for systems neuroscience investigation. In the course of this work I have provided outstanding training to 33 graduate students, and 37 postdocs, most of whom are pursuing research careers at major universities. Over the next 5 years, my overall programme (including other support) will provide training for at least 4 undergrads, 10 graduates and 7 postdocs, as we continue to study the impact of hippocampal back projections to the neocortex on neural coding and neural plasticity in that structure. Understanding this impact is key to understanding why, in the absence of a functional hippocampus, the neocortex is unable to form new memories or to extract general knowledge from experience efficiently. It is also key to understanding a mode of computational knowledge acquisition and representation that may have far reaching impacts on information and computer technology. "What does the hippocampus (HC) do for neocortex (NC)?" This question is addressed under three specific subtopics: 1) How does HC affect the actual coding properties of NC neurons? In particular, is the apparent spatial modulation of object encoding and behavior in some NC regions inherited from "place coding" in HC? Do NC coding statistics change as the brain refines its model of the world, and does HC enable such changes? 2) To what degree does the reactivation of memory traces observed in NC during rest and slow-wave-sleep depend on HC output? Is the dependence different for new memories compared to reinstated or spontaneously retrieved old memories? For new memories, is HC required for NC reactivation per se, or rather is it merely required for synchronizing cortical reactivation over broad areas? Which parts of NC are most strongly activated by HC outflow during memory reactivation? Does the relative timing between NC and HC memory reactivation change as memories gradually become consolidated (i.e., does HC initially lead HC and subsequently follow it)? 3) Is HC necessary for learning-associated dendritic spine plasticity in NC? Does HC contribute to the regulation of expression of NC neurotrophins which are crucial to neuroplasticity in NC? These questions are addressed using various combinations of multi-neuron recording, using electrophysiological and optical imaging methods, neocortical voltage recording, structural and functional imaging of NC dendritic spines in vivo, and immunochemical quantification of neurotrophic factors, in animals with intact or inactivated HC function.
我的研究项目集中在记忆的神经计算基础上,以及神经元群体之间的动态相互作用,这些相互作用导致大脑有能力创建ITS的适应性模型。在过去的35年里,我在了解中枢突触可塑性机制、空间信息处理、皮质-海马区相互作用和记忆巩固方面做出了重大贡献,并为系统神经科学研究提供了显著先进的技术。在这项工作中,我为33名研究生和37名博士后提供了出色的培训,他们中的大多数都在主要大学从事研究工作。在接下来的5年里,我的整个计划(包括其他支持)将为至少4名本科生、10名研究生和7名博士后提供培训,因为我们将继续研究海马向新皮质的背部投影对该结构中神经编码和神经可塑性的影响。理解这种影响是理解为什么在没有功能正常的海马体的情况下,新大脑皮层无法形成新的记忆或有效地从经验中提取一般知识的关键。它也是理解一种可能对信息和计算机技术产生深远影响的计算知识获取和表示模式的关键。“海马体(HC)对新皮质(NC)有什么作用?”这个问题在三个具体的小主题下被解决:1)HC如何影响NC神经元的实际编码特性?特别是,一些NC区域对物体编码和行为的明显空间调制是不是从HC的位置编码遗传来的?NC编码统计数据是否随着大脑精炼其世界模型而改变,而HC是否使这种改变成为可能?2)在休息和慢波睡眠期间,NC中观察到的记忆痕迹的重新激活在多大程度上依赖于HC的输出?与恢复或自发恢复的旧记忆相比,新记忆的依赖性是否不同?对于新记忆,NC重新激活本身是否需要HC,或者更确切地说,它仅仅是在广泛区域同步皮质重新激活所必需的吗?在记忆重新激活过程中,NC的哪些部分被HC流出激活得最强烈?NC和HC之间的记忆重新激活的相对时间是否随着记忆的逐渐巩固而改变(即,HC最初领先HC,然后跟随HC)吗?3)HC对于NC学习相关的树突可塑性是必要的吗?HC是否参与了对NC神经可塑性至关重要的NC神经营养因子的表达调节?在HC功能完整或失活的动物中,通过多神经元记录、使用电生理和光学成像方法、新皮质电压记录、活体NC树突棘的结构和功能成像以及神经营养因子的免疫化学定量的各种组合来解决这些问题。
项目成果
期刊论文数量(0)
专著数量(0)
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McNaughton, Bruce的其他文献
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{{ truncateString('McNaughton, Bruce', 18)}}的其他基金
Hippocampal cortical interactions and the extraction of knowledge from episodic memory
海马皮层相互作用和从情景记忆中提取知识
- 批准号:
RGPIN-2017-03857 - 财政年份:2021
- 资助金额:
$ 6.56万 - 项目类别:
Discovery Grants Program - Individual
Hippocampal cortical interactions and the extraction of knowledge from episodic memory
海马皮层相互作用和从情景记忆中提取知识
- 批准号:
RGPIN-2017-03857 - 财政年份:2020
- 资助金额:
$ 6.56万 - 项目类别:
Discovery Grants Program - Individual
Hippocampal cortical interactions and the extraction of knowledge from episodic memory
海马皮层相互作用和从情景记忆中提取知识
- 批准号:
RGPIN-2017-03857 - 财政年份:2018
- 资助金额:
$ 6.56万 - 项目类别:
Discovery Grants Program - Individual
Hippocampal cortical interactions and the extraction of knowledge from episodic memory
海马皮层相互作用和从情景记忆中提取知识
- 批准号:
RGPIN-2017-03857 - 财政年份:2017
- 资助金额:
$ 6.56万 - 项目类别:
Discovery Grants Program - Individual
"The hippocampal indexing theory: impact of hippocampal-neocortical backprojections on neocortical neurodynamics, plasticity and coding"
“海马索引理论:海马-新皮质反投影对新皮质神经动力学、可塑性和编码的影响”
- 批准号:
418442-2012 - 财政年份:2016
- 资助金额:
$ 6.56万 - 项目类别:
Discovery Grants Program - Individual
"The hippocampal indexing theory: impact of hippocampal-neocortical backprojections on neocortical neurodynamics, plasticity and coding"
“海马索引理论:海马-新皮质反投影对新皮质神经动力学、可塑性和编码的影响”
- 批准号:
418442-2012 - 财政年份:2015
- 资助金额:
$ 6.56万 - 项目类别:
Discovery Grants Program - Individual
"The hippocampal indexing theory: impact of hippocampal-neocortical backprojections on neocortical neurodynamics, plasticity and coding"
“海马索引理论:海马-新皮质反投影对新皮质神经动力学、可塑性和编码的影响”
- 批准号:
429438-2012 - 财政年份:2014
- 资助金额:
$ 6.56万 - 项目类别:
Discovery Grants Program - Accelerator Supplements
"The hippocampal indexing theory: impact of hippocampal-neocortical backprojections on neocortical neurodynamics, plasticity and coding"
“海马索引理论:海马-新皮质反投影对新皮质神经动力学、可塑性和编码的影响”
- 批准号:
418442-2012 - 财政年份:2014
- 资助金额:
$ 6.56万 - 项目类别:
Discovery Grants Program - Individual
"The hippocampal indexing theory: impact of hippocampal-neocortical backprojections on neocortical neurodynamics, plasticity and coding"
“海马索引理论:海马-新皮质反投影对新皮质神经动力学、可塑性和编码的影响”
- 批准号:
429438-2012 - 财政年份:2013
- 资助金额:
$ 6.56万 - 项目类别:
Discovery Grants Program - Accelerator Supplements
"The hippocampal indexing theory: impact of hippocampal-neocortical backprojections on neocortical neurodynamics, plasticity and coding"
“海马索引理论:海马-新皮质反投影对新皮质神经动力学、可塑性和编码的影响”
- 批准号:
418442-2012 - 财政年份:2013
- 资助金额:
$ 6.56万 - 项目类别:
Discovery Grants Program - Individual
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- 资助金额:
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