Plasticity of development of vision and of the mammalian visual pathways

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The objective of my research is to understand how the development of the pathways in the brain that process vision, and vision itself, is influenced by what an animal sees early in life, the so-called nature-nuture issue with respect to vision. From studies on animal species that have visual systems organized like ours for accurate binocular depth perception (stereoscopic vision), it is known that there are so called “critical periods” in development during which abnormal visual input can effect the development of the visual pathways that result in visual impairments. More recently it has been shown that prior to birth the anatomical organization of the visual system develops according to a series of genetic instructions to a level that can be quite sophisticated. The blueprint established by genetic instructions provides the template that both allows and constrains the extent to which visual experience after birth can further influence development. A few years ago I introduced a new method to examine the role of experience in development by sequentially pitting two visual inputs against each other each day. For part of the day animals receive normal visual input while for the remainder they receive grossly abnormal input, in the form of visual input to just one eye. The first visual input matches the anatomical template established by genetic instruction at birth, while the other input does not. We reasoned that visual input that matches the template at birth would be favoured over the other. The results clearly favour this possibility; binocular visual input that amounted to just 30% of the total exposure outweighed or protected against much longer daily periods of monocular exposure to permit the development of normal visual acuity in both eyes as well normal appearance of the visual cortex. The same strategy will be used to establish the far more strict requirements for development of normal stereoscopic vision, the ability to use information from the two eyes to provide a vivid impression of depth as in 3-D movies. Another study will examine the requirements for development of normal visual acuity and stereoscopic vision in the presence of intermittent misalignment of the two eyes as occurs in strabismus (a” turned eye”) that will be simulated with prisms. We will follow-up to a recent unexpected finding of ours, that kittens placed in total darkness for 10 days before the age of 11 weeks suffer a severe but temporary loss of vision by determining some of the conditions such as the length of darkness under which this effects occur. As in my past studies, the vision of each eye for these various studies is evaluated by use of a jumping stand where kittens are required to jump for a food reward and petting to one of two stimuli placed side by side below them.