Reverse engineering brain networks for scene and object processing with non-invasive neuromodulation

通过非侵入性神经调节对大脑网络进行逆向工程，用于场景和对象处理

• 批准号: RGPIN-2017-05745
• 负责人: Steeves, Jennifer
• 金额: $ 2.84万
• 依托单位: York University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=631526
• 关键词: Reverse; engineering; brain; networks; scene

OBJECTIVE: Mounting evidence from behavioural measures, neuroimaging and clinical data has shown that objects and scenes are processed independently and that, counterintuitively, a scene can be categorized without the need to recognize any of its constituent objects. The goal of this research program is to examine the relationship between object and scene processing and, in particular, the contribution of object-selective cortical areas to scene processing and their corollary. My laboratory has demonstrated that non-invasive neuromodulation of object-selective cortex with transcranial magnetic stimulation (TMS) has remote effects across the brain in scene processing regions and behaviourally, it alters our ability to perceive scenes. This observation suggests for the first time that object and scene processing may not be as independent as previously thought but might instead involve mutual connections. In the proposed research program I will assess the functional connectivity of object-preferential cortex on scene perception and scene-preferential cortex on object perception at both the behavioural and neural level.

目的：来自行为测量、神经成像和临床数据的越来越多的证据表明，物体和场景是独立处理的，与直觉相反，场景可以在不需要识别其任何组成物体的情况下进行分类。本研究计划的目的是研究对象和场景处理之间的关系，特别是对象选择皮质区域对场景处理及其推论的贡献。我的实验室已经证明，经颅磁刺激（TMS）对目标选择皮层的非侵入性神经调节在整个大脑的场景处理区域具有远程影响，从行为上讲，它改变了我们感知场景的能力。这一观察首次表明，物体和场景的处理可能不像之前认为的那样独立，而是可能涉及相互联系。在本研究计划中，我将在行为和神经水平上评估物体优先皮层对场景感知和场景优先皮层对物体感知的功能连通性。