Alpha-amanitin: synthetic derivatives for applications in targeted therapy

α-鹅膏蕈碱：用于靶向治疗的合成衍生物

• 批准号: 371282
• 负责人: Perrin David M
• 金额: $ 29.54万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-09-01 至 2021-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=371282&lang=en
• 关键词: Bioconjugate; Natural Product; Peptide; Targeted Therapy

The deadly mushroom, A. phalloides produces a unique toxin known as amanitin that has a desired property of being able to kill both growing cells (easy) and quiescent cells (more difficult). This uniform toxicity is exciting for use in cancer therapy sin

致命蘑菇A.鬼笔状菌产生一种称为鹅膏毒肽的独特毒素，其具有能够杀死生长细胞（容易）和静止细胞（更困难）的所需性质。 这种均匀的毒性令人兴奋地用于癌症治疗，