Solid-State Nuclear Magnetic Resonance of Biomaterials

生物材料的固态核磁共振

• 批准号: RGPIN-2016-05447
• 负责人: Michaelis, Vladimir
• 金额: $ 2.55万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=632517
• 关键词: Solid; State; Nuclear; Magnetic; Resonance

Biomaterials encompass a diverse range of chemical systems from bioactive catalysts to amorphous structural scaffolds with tremendous potential for chemically tuning specific functions. Identifying molecular-level structure of amorphous biomaterials is inherently difficult due to their disordered nature; historically, researchers have relied on a trial-and-error approach. Nuclear magnetic resonance (NMR) spectroscopy is a non-destructive technique that is sensitive to the local chemical environment. This unique ability to probe locally and tune to specific nuclei has prompted NMR to become one of the most powerful structural tools at our disposal to study disordered biological and inorganic materials. Our proposed research is to use solid-state NMR spectroscopy to study glass ionomer cements as well as bioglasses and glass-ceramics. To improve biological function of glass ionomer cements and develop bioglasses capable of small molecule delivery requires a detailed understanding of how network-modifying elements affect bulk and surface structure at the biological:inorganic interface. Gaining a perspective on the structure-property relationships within these complex chemical systems will ultimate lead to our ability to design

生物材料包括从生物活性催化剂到具有化学调节特定功能的巨大潜力的无定形结构支架的各种化学系统。由于无定形生物材料的无序性质，识别其分子水平结构本质上是困难的;从历史上看，研究人员一直依赖于试错法。核磁共振（NMR）光谱是一种对局部化学环境敏感的非破坏性技术。这种独特的局部探测和调谐特定核的能力促使NMR成为我们研究无序生物和无机材料的最强大的结构工具之一。我们的研究计划是使用固态核磁共振光谱来研究玻璃离子水门汀以及微晶玻璃和玻璃陶瓷。为了改善玻璃离子水门汀的生物功能和开发能够传递小分子的水门汀，需要详细了解网络修饰元素如何影响生物：无机界面的体积和表面结构。在这些复杂的化学系统中获得结构-性质关系的观点将最终导致我们的设计能力