Solid-State Nuclear Magnetic Resonance of Biomaterials

生物材料包括各种化学体系，从生物活性催化剂到具有化学调节特定功能的巨大潜力的无定形结构支架。由于非晶态生物材料的无序性质，识别其分子级结构本身就很困难；从历史上看，研究人员一直依赖于一种反复试验的方法。核磁共振波谱是一种对局部化学环境敏感的非破坏性技术。这种独特的局部探测和调谐特定原子核的能力促使核磁共振成为我们可以使用的最强大的结构工具之一，用于研究无序的生物和无机材料。我们提出的研究是利用固体核磁共振波谱来研究玻璃离子水门汀以及生物玻璃和微晶玻璃。为了改善玻璃离子水门汀的生物功能，开发能够输送小分子的生物玻璃，需要详细了解网络修饰元件如何影响生物-无机界面的整体和表面结构。了解这些复杂化学体系中的结构-性质关系将最终导致我们有能力设计

Biomaterials encompass a diverse range of chemical systems from bioactive catalysts to amorphous structural scaffolds with tremendous potential for chemically tuning specific functions. Identifying molecular-level structure of amorphous biomaterials is inherently difficult due to their disordered nature; historically, researchers have relied on a trial-and-error approach. Nuclear magnetic resonance (NMR) spectroscopy is a non-destructive technique that is sensitive to the local chemical environment. This unique ability to probe locally and tune to specific nuclei has prompted NMR to become one of the most powerful structural tools at our disposal to study disordered biological and inorganic materials. Our proposed research is to use solid-state NMR spectroscopy to study glass ionomer cements as well as bioglasses and glass-ceramics. To improve biological function of glass ionomer cements and develop bioglasses capable of small molecule delivery requires a detailed understanding of how network-modifying elements affect bulk and surface structure at the biological:inorganic interface. Gaining a perspective on the structure-property relationships within these complex chemical systems will ultimate lead to our ability to design