Solid-State Nuclear Magnetic Resonance of Biomaterials
Solid-State Nuclear Magnetic Resonance of Biomaterials
批准号:
RGPIN-2016-05447
负责人:
Michaelis, Vladimir
金额:
$2.55万
依托单位:
依托单位国家:
加拿大
项目类别:
Discovery Grants Program - Individual
财政年份:
2017
资助国家:
加拿大
项目状态:
已结题
起止时间:
2017-01-01 至 2018-12-31
中文摘要
生物材料包括各种化学体系,从生物活性催化剂到具有化学调节特定功能的巨大潜力的无定形结构支架。由于非晶态生物材料的无序性质,识别其分子级结构本身就很困难;从历史上看,研究人员一直依赖于一种反复试验的方法。核磁共振波谱是一种对局部化学环境敏感的非破坏性技术。这种独特的局部探测和调谐特定原子核的能力促使核磁共振成为我们可以使用的最强大的结构工具之一,用于研究无序的生物和无机材料。我们提出的研究是利用固体核磁共振波谱来研究玻璃离子水门汀以及生物玻璃和微晶玻璃。为了改善玻璃离子水门汀的生物功能,开发能够输送小分子的生物玻璃,需要详细了解网络修饰元件如何影响生物-无机界面的整体和表面结构。了解这些复杂化学体系中的结构-性质关系将最终导致我们有能力设计
英文摘要
Biomaterials encompass a diverse range of chemical systems from bioactive catalysts to amorphous structural scaffolds with tremendous potential for chemically tuning specific functions. Identifying molecular-level structure of amorphous biomaterials is inherently difficult due to their disordered nature; historically, researchers have relied on a trial-and-error approach. Nuclear magnetic resonance (NMR) spectroscopy is a non-destructive technique that is sensitive to the local chemical environment. This unique ability to probe locally and tune to specific nuclei has prompted NMR to become one of the most powerful structural tools at our disposal to study disordered biological and inorganic materials. Our proposed research is to use solid-state NMR spectroscopy to study glass ionomer cements as well as bioglasses and glass-ceramics. To improve biological function of glass ionomer cements and develop bioglasses capable of small molecule delivery requires a detailed understanding of how network-modifying elements affect bulk and surface structure at the biological:inorganic interface. Gaining a perspective on the structure-property relationships within these complex chemical systems will ultimate lead to our ability to design
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Magnetic Resonance Spectroscopy of Next Generation Materials
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批准号:RGPIN-2021-02540
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.11万
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财政年份:2022
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负责人:Michaelis, Vladimir
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依托单位:
Magnetic Resonance of Advanced Materials
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批准号:CRC-2020-00352
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项目类别:Canada Research Chairs
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资助金额:$8.74万
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财政年份:2022
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负责人:Michaelis, Vladimir
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依托单位:
Magnetic Resonance Of Advanced Materials
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批准号:CRC-2020-00352
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项目类别:Canada Research Chairs
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资助金额:$8.74万
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财政年份:2021
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负责人:Michaelis, Vladimir
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依托单位:
Magnetic Resonance Spectroscopy of Next Generation Materials
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批准号:RGPIN-2021-02540
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.11万
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财政年份:2021
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负责人:Michaelis, Vladimir
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依托单位:
Magnetic Resonance of Advanced Materials
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批准号:1000233031-2019
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项目类别:Canada Research Chairs
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资助金额:$6.92万
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财政年份:2020
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负责人:Michaelis, Vladimir
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依托单位:
Solid-State Nuclear Magnetic Resonance of Biomaterials
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批准号:RGPIN-2016-05447
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.55万
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财政年份:2020
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负责人:Michaelis, Vladimir
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依托单位:
Solid-State Nuclear Magnetic Resonance of Biomaterials
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批准号:RGPIN-2016-05447
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.55万
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财政年份:2019
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负责人:Michaelis, Vladimir
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依托单位:
Solid-State Nuclear Magnetic Resonance of Biomaterials
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批准号:RGPIN-2016-05447
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.55万
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财政年份:2018
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负责人:Michaelis, Vladimir
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依托单位:
Boosting Benchtop NMR Sensitivity for Solids
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批准号:523093-2018
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项目类别:Engage Grants Program
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资助金额:$1.82万
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财政年份:2018
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负责人:Michaelis, Vladimir
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依托单位:
Decoding Coke Formation during Ethane Cracking using Nuclear Magnetic Resonance Spectroscopy
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批准号:497293-2016
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项目类别:Engage Grants Program
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资助金额:$1.82万
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财政年份:2016
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负责人:Michaelis, Vladimir
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依托单位:
Solid-State Nuclear Magnetic Resonance of Biomaterials
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批准号:RGPIN-2016-05447
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项目类别:Discovery Grants Program - Individual
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资助金额:$2.55万
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财政年份:2016
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负责人:Michaelis, Vladimir
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依托单位:
Developing 17O NMR and High Field DNP NMR for Structure Elucidation in Biological Solids
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批准号:469005-2014
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项目类别:Banting Postdoctoral Fellowships Tri-council
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资助金额:$3.4万
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财政年份:2015
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负责人:Michaelis, Vladimir
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依托单位:
An Urgent Triple Resonance NMR Upgrade for Materials Characterization
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批准号:RTI-2016-00337
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项目类别:Research Tools and Instruments
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资助金额:$10.93万
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财政年份:2015
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负责人:Michaelis, Vladimir
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依托单位:
Developing 17O NMR and High Field DNP NMR for Structure Elucidation in Biological Solids
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批准号:469005-2014
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项目类别:Banting Postdoctoral Fellowships Tri-council
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资助金额:$5.1万
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财政年份:2014
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负责人:Michaelis, Vladimir
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依托单位:
Dynamics nuclear polarization NMR of nanoliter samples at ultrahigh magnetic fields
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批准号:388248-2010
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项目类别:Postdoctoral Fellowships
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资助金额:$1.46万
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财政年份:2012
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负责人:Michaelis, Vladimir
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依托单位:
Dynamics nuclear polarization NMR of nanoliter samples at ultrahigh magnetic fields
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批准号:388248-2010
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项目类别:Postdoctoral Fellowships
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资助金额:$2.91万
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财政年份:2011
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负责人:Michaelis, Vladimir
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依托单位:
Solid state nuclear magnetic resonance studies of terany borosilicate glass materials
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批准号:362501-2008
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项目类别:Postgraduate Scholarships - Doctoral
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资助金额:$1.53万
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财政年份:2010
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负责人:Michaelis, Vladimir
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依托单位:
Dynamics nuclear polarization NMR of nanoliter samples at ultrahigh magnetic fields
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批准号:388248-2010
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项目类别:Postdoctoral Fellowships
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资助金额:$1.46万
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财政年份:2010
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负责人:Michaelis, Vladimir
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依托单位:
Solid state nuclear magnetic resonance studies of terany borosilicate glass materials
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批准号:362501-2008
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项目类别:Postgraduate Scholarships - Doctoral
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资助金额:$1.53万
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财政年份:2009
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负责人:Michaelis, Vladimir
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依托单位:
Solid state nuclear magnetic resonance studies of terany borosilicate glass materials
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批准号:362501-2008
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项目类别:Postgraduate Scholarships - Doctoral
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资助金额:$1.53万
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财政年份:2008
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负责人:Michaelis, Vladimir
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依托单位:
国内基金
海外基金
Simulation and certification of the ground state of many-body systems on quantum simulators
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批准号:--
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项目类别:--
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资助金额:40万元
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批准年份:2020
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负责人:Abolfazl Bayat
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依托单位:
Cortical control of internal state in the insular cortex-claustrum region
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批准号:--
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项目类别:--
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资助金额:25万元
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批准年份:2020
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负责人:Robert Konrad Naumann
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依托单位:
微波有源Scattering dark state粒子的理论及应用研究
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批准号:61701437
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项目类别:青年科学基金项目
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资助金额:28.0万元
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批准年份:2017
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负责人:李欢
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依托单位: