Boosting Benchtop NMR Sensitivity for Solids

提高固体的台式 NMR 灵敏度

• 批准号: 523093-2018
• 负责人: Michaelis, Vladimir
• 金额: $ 1.82万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=659729
• 关键词: Boosting; Benchtop; NMR; Sensitivity; Solids

Nuclear magnetic resonance spectroscopy is a highly valued analytical tool within industry and science, able to**reveal atomic- and molecular-level chemical structure in organic and inorganic samples. The innovative**platform offered through a benchtop NMR designed has evolved a once large and cumbersome instrument**footprint into strategic research areas once inaccessible including inert air gloveboxes and in field applications.**The next leap in innovation and advancement is to increase the overall sensitivity of the method broadening its**far-reaching capabilities into solids, active pharmaceutical ingredients and environmental applications where**low analyte situations are common. The Nanalysis-Michaelis engagement strategically aims to tackle these**current challenges facing this industry, positioning Nanalysis to further develop applications and method**development into new industrial, research and teaching areas. Using cryogenic technology including electrical**and sample cooling has the ability to increase sensitivity while serving as a conduit for variable temperature**characterization capabilities. Further hardware development will offer extensions into new research areas**including solid-state NMR of nanoparticles, J-couplings, and single-crystal studies.

核磁共振波谱是工业和科学领域中非常有价值的分析工具，能够揭示有机和无机样品中的原子和分子水平的化学结构。通过台式核磁共振设计提供的创新平台已经将曾经庞大而笨重的仪器发展到曾经无法进入的战略研究领域，包括惰性空气手套箱和现场应用。创新和进步的下一个飞跃是提高该方法的整体灵敏度，将其广泛的能力扩展到固体，活性药物成分和低分析物情况常见的环境应用中。Nanalysis- michaelis合作的战略目标是解决该行业当前面临的挑战，定位Nanalysis进一步开发应用程序和方法开发到新的工业，研究和教学领域。使用低温技术，包括电气和样品冷却，能够提高灵敏度，同时作为可变温度表征能力的管道。进一步的硬件开发将提供扩展到新的研究领域**，包括纳米颗粒的固态核磁共振，j -耦合和单晶研究。